Novel cyanocombretastatins as potent tubulin polymerisation inhibitors was written by Jalily, Pouria H.;Hadfield, John A.;Hirst, Nicholas;Rossington, Steven B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Electric Literature of C8H7IO2 This article mentions the following:
A series of novel cyanocombretastatins bearing a 3,4,5-trimethoxyphenyl moiety combined with a variety of substituted Ph rings, were synthesized and their antitumor activity was evaluated. The Z-cyanocombretastatins were synthesized in a one-step protocol in high purity and yield. Fluoro, bromo, iodo, and derivatives with boronic acid and an ethyne function at meta position of the B ring were synthesized. In vitro MTT bioassays against human chronic myelogenous leukemia (K562) and transfected breast adenocarcinoma (MDA NQO1) cell lines, revealed promising IC50 inhibitory values in nanomolar range (<50 nM). Introduction of a nitrile function on the olefinic bond not only increased the cytotoxicity of the less active Z-isomers but rendered the analogs as moderate to potent inhibitors of tubulin polymerization comparable to that of CA-4 (IC50 = 2.2 μM). Thus, compound I (IC50 = 6.7 μM) was identified as a lead candidate for a further evaluation. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Electric Literature of C8H7IO2).
3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Electric Literature of C8H7IO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com