Novel imidazole-based histamine H3 antagonists was written by Jablonowski, Jill A.;Ly, Kiev S.;Bogenstaetter, Michael;Dvorak, Curt A.;Boggs, Jamin D.;Dvorak, Lisa K.;Lord, Brian;Miller, Kirsten L.;Mazur, Curt;Wilson, Sandy J.;Lovenberg, Timothy W.;Carruthers, Nicholas I.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Quality Control of 1-Chloro-4-iodobutane This article mentions the following:
A novel series of imidazole containing histamine H3 receptor ligands, i.e. I, were investigated and found to be potent functional antagonists. After improving the stability of these mols. towards liver microsomes, these compounds were found to have no appreciable affinity for CYP P450s. Subsequent in vivo experiments showed significant brain uptake of (4-chloro-phenyl)-[2-(1-isopropyl-piperidin-4-ylmethoxy)-3-methyl-3H-imidazol-4-yl]-methanone I. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Quality Control of 1-Chloro-4-iodobutane).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Quality Control of 1-Chloro-4-iodobutane
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com