Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides was written by Gu, Yang;Leng, Xuebing;Shen, Qilong. And the article was included in Nature Communications in 2014.Synthetic Route of C11H14INO This article mentions the following:
A cooperative dual palladium/silver catalyst system for direct difluoromethylation of aryl bromides and iodides under mild conditions is reported. The system is developed by initial preparation of the putative intermediates in the dual-catalytic cycles, followed by studying the elemental steps to demonstrate the viability of the proposed cooperative catalytic cycle. The reaction is compatible with a variety of functional groups such as ester, amide, protected phenoxide, protected ketone, cyclopropyl, bromide, and heteroaryl subunits such as pyrrole, benzothiazole, carbazole or pyridine. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Synthetic Route of C11H14INO).
N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Synthetic Route of C11H14INO
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com