Isolation of macrocyclic metacyclophanes from the attempted synthesis of [7.0]metacyclophanes of the myricanone series by Thorpe-Ziegler intramolecular cyclization of diaryls substituted by ω-cyanoalkyl chains was written by Dansou, Benedicte;Pichon, Christophe;Dhal, Robert;Brown, Eric;Mille, Stephane. And the article was included in European Journal of Organic Chemistry in 2000.Electric Literature of C8H7IO2 This article mentions the following:
The syntheses of biphenyls I and II substituted by two ω-cyanoalkyl chains (one on each ring) are described. Treatment of the unsym. I with NaN(Me)Ph in a Thorpe-Ziegler reaction failed to give any definite product. Under the same conditions, sym. II led to an isomeric mixture of dimeric enamino nitriles III [X = CH2C(NH2):C(CN), X1 = CH2C(NH2):C(CN) or C(CN):C(NH2)CH2]. Mild acidic hydrolysis of the latter yielded the isomeric β-keto nitriles III [X = CH2COCH(CN), X1 = CH(CN)COCH2], whereas more drastic hydrolytic conditions led to the macrocyclic diketone III (X, X1 = CH2COCH2). In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Electric Literature of C8H7IO2).
3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Electric Literature of C8H7IO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com