Reductive Cross-Coupling of α-Oxy Halides Enabled by Thermal Catalysis, Photocatalysis, Electrocatalysis, or Mechanochemistry was written by Zhu, Chen;Lee, Shao-Chi;Chen, Haifeng;Yue, Huifeng;Rueping, Magnus. And the article was included in Angewandte Chemie, International Edition in 2022.Synthetic Route of C8H5IS This article mentions the following:
A reductive cross-coupling reaction of α-oxy halides, simply generated from aldehydes, with a series of C(sp2)- and C(sp)-electrophiles was reported. A wide range of aryl and heteroatom aryl halides, vinyl bromides, alkynyl bromides, and acyl chlorides react with unhindered and hindered aldehyde-derived α-oxy halides by providing protected alcs. as well as α-hydroxy ketones. Noteworthy, the reductive couplings are achieved not only through thermal catalysis with the use of metal reductants but also by photocatalysis, electrochem., and mechanochem. The unrestricted interchange of the four strategies indicates their underlying mechanistic similarities. The generation of NiI intermediate was proposed to be the key point for ketyl radical formation via a single-electron transfer (SET) event, which was rationalized by an array of control experiments and d. functional theory (DFT) calculations In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Synthetic Route of C8H5IS).
3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Synthetic Route of C8H5IS
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com