Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)-H Arylation with a Transient Directing Group was written by Provencher, Philip A.;Hoskin, John F.;Wong, Jonathan J.;Chen, Xiangyang;Yu, Jin-Quan;Houk, K. N.;Sorensen, Erik J.. And the article was included in Journal of the American Chemical Society in 2021.Name: (5-Fluoro-2-iodophenyl)methanol This article mentions the following:
Methylene-selective C-H functionalization is a significant hurdle that remains to be addressed in the field of Pd(II) catalysis. A Pd(II)-catalyzed synthesis of benzocyclobutenes I (R = 3-I, 2-F, 3,4-(F)2, etc.; R1 = H, Me, Bu; R2 = Me, Et) by methylene-selective C(sp3)-H arylation of ketones has been described. The reaction utilizes glycine as a transient directing group and a 2-pyridone ligand, which may govern the methylene selectivity by making intimate mol. associations with the substrate during concerted metalation-deprotonation. This reaction is shown to be highly selective for intramol. methylene C(sp3)-H arylation, thus enabling sequential C(sp3)-H functionalization. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Name: (5-Fluoro-2-iodophenyl)methanol).
(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Name: (5-Fluoro-2-iodophenyl)methanol
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com