Programmable synthesis of multiply arylated cubanes through C-H metalation and arylation was written by Okude, Ryo;Mori, Genki;Yagi, Akiko;Itami, Kenichiro. And the article was included in Chemical Science in 2020.Category: iodides-buliding-blocks This article mentions the following:
Cubane (C8H8), a cubic alkane, was long attracted attention owing to its unique 3D structure. In order to utilize the cubane scaffold widely in science and technol., a powerful method for synthesizing diverse cubane derivatives was required. The synthesis of mono-, di-, tri-, and tetra-arylated cubaneS was discussed. Directed ortho-metalation with lithium base/alkyl zinc and subsequent palladium-catalyzed arylation enabled C-H metalation and arylation of cubane. This reaction allows the late-stage and regioselective installation of a wide range of aryl groups, realizing the first programmable synthesis of diverse multiply arylated cubanes. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Category: iodides-buliding-blocks).
N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Category: iodides-buliding-blocks
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com