Pd-Catalyzed Asymmetric Three-Component Allenol Carbopalladation and Allylic Cycloaddition Cascade: A Route to Functionalized Tetrahydrofurans was written by Li, Hongfang;Khan, Ijaz;Li, Qun;Zhang, Yong Jian. And the article was included in Organic Letters in 2022.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene This article mentions the following:
The first Pd-catalyzed asym. three-component reaction of 2,3-allenol, aryl iodides RI (R = 4-methoxyphenyl, 2H-1,3-benzodioxol-5-yl, thiophen-2-yl, etc.) and 2-arylmethylenemalononitriles R1CH=C(CN)2 (R1 = 2-methylphenyl, 2H-1,3-benzodioxol-5-yl, furan-2-yl, etc.) has been developed via an allenol carbopalladation and an allylic cycloaddition cascade. This process allows rapid access to substituted tetrahydrofurans I bearing diverse functional groups in good yields with high diastereoselectivities and excellent enantioselectivities. The concise total synthesis of a lignan, (-)-2-episesaminone, has been achieved by the elaboration of a functionalized THF obtained from this reaction. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Recommanded Product: 4-Iodo-1,2-dimethoxybenzene).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com