Phase transfer catalyzed asymmetric alkylations of imine glycinamides was written by Kumar, Sanjeev;Ramachandran, Uma. And the article was included in Tetrahedron: Asymmetry in 2003.Formula: C4H8ClI This article mentions the following:
Herein we report the use of achiral imine glycinamides as substrates for asym. alkylations using chiral phase-transfer catalysts for the first time. Initially tried for obtaining a key intermediate for the synthesis of levobupivacaine, we expanded the study to other N-mono and N,N-disubstituted imine glycinamides. A possible explanation for the lower enantioselectivity observed in the case of alkylation of N-monosubstituted as compared to N,N-disubstituted glycinamides is also provided. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Formula: C4H8ClI).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Formula: C4H8ClI
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com