A mild approach for the synthesis of indoles from N-(2-iodo-aryl)formamides and phenylacetylene by a copper(I)- and palladium-catalyzed cascade process was written by Ahmed, Atiur;Ghosh, Munmun;Dhara, Shubhendu;Ray, Jayanta K.. And the article was included in Synlett in 2014.Computed Properties of C6H4Cl2IN This article mentions the following:
An efficient one-pot synthesis of phenyl-indoles I [R = 5-CH3, 5,6-Cl2, 5-Br, 5-F, etc.] via copper and palladium catalyzed cascade reaction of iodophenylformamide and phenylacetylene in DMF is described. The cascade reaction comprises a Sonogashira cross-coupling, an intramol. CN bond formation, and hydrolysis of the intermediate indole-1-carbaldehyde promoted by the same catalyst and base systems. This methodol. offers several significant advantages such as mild reaction conditions, overall high yields, easy functionalization and operational simplicity. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7Computed Properties of C6H4Cl2IN).
4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Computed Properties of C6H4Cl2IN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com