Rapid Access to Azabicyclo[3.3.1]nonanes by a Tandem Diverted Tsuji-Trost Process was written by Steeds, Hannah G.;Knowles, Jonathan P.;Yu, Wai L.;Richardson, Jeffery;Cooper, Katie G.;Booker-Milburn, Kevin I.. And the article was included in Chemistry – A European Journal in 2020.SDS of cas: 877264-43-2 This article mentions the following:
A three-step synthesis of 2-azabicyclo[3.3.1]nonane ring system such as I [R = n-pentyl, Bn, Ts, etc.] from simple pyrroles, employing a combined photochem./palladium-catalyzed approach was reported. Substrate scope was broad, allowing incorporation of a wide range of functionality relevant to medicinal chem. Mechanistic studies demonstrated that process occurs by acid-assisted C-N bond cleavage followed by β-hydride elimination to form a reactive diene, demonstrated that efficient control of what might be considered off-cycle reactions can result in productive tandem catalytic processes. This represented a short and versatile route to biol. important morphan scaffold. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2SDS of cas: 877264-43-2).
(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.SDS of cas: 877264-43-2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com