Synthesis and in vivo brain distribution of carbon-11-labeled δ-opioid receptor agonists was written by Pichika, Rama;Jewett, Douglas M.;Sherman, Philip S.;Traynor, John R.;Husbands, Stephen M.;Woods, James H.;Kilbourn, Michael R.. And the article was included in Nuclear Medicine and Biology in 2010.Application of 77350-52-8 This article mentions the following:
Three new radiolabeled compounds, [11C]SNC80 ((+)-4-[(αR)-α-{(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl}]-3-[11C]methoxybenzyl-N,N-diethylbenzamide), N,N-diethyl-4-(3-methoxyphenyl-1-[11C]methylpiperidin-4-ylidenemethyl)benzamide and N,N-diethyl-4-[(1-[11C]methylpiperidin-4-ylidene)phenylmethyl]benzamide, were prepared as potential in vivo radiotracers for the δ-opioid receptor. Each compound was synthesized by alkylation of the appropriate desmethyl compounds using [11C]methyl triflate. In vivo biodistribution studies in mice showed very low initial brain uptake of all three compounds and no regional specific binding for [11C]SNC80. A monkey positron emission tomog. study of [11C]SNC80 confirmed low brain permeability and uniform regional distribution of this class of opioid agonists in a higher species. Opioid receptor ligands of this structural class are thus unlikely to succeed as in vivo radiotracers, likely due to efficient exclusion from the brain by the P-glycoprotein efflux transporter. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Application of 77350-52-8).
N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Application of 77350-52-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com