Room temperature HFIP/Ag-promoted palladium-catalyzed C-H functionalization of benzothiazole with iodoarenes was written by Kori, Santosh;Bhujbal, Yuvraj;Vadagaonkar, Kamlesh;Kapdi, Anant R.;Kommyreddy, Saidurga Prasad;Gharpure, Santosh J.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Reference of 5460-32-2 This article mentions the following:
A versatile synthetic protocol involving the room temperature direct arylation of benzothiazoles I (R = H, Me, Cl, F) with a wide variety of iodoarenes R1I (R1 = C6H5, 4-ClC6H4, 2-naphthyl, etc.) under Ag-promoted Pd-catalyzed conditions in HFIP as the reaction solvent has been presented. A sequential HFIP-promoted selective iodination of arenes followed by Pd-catalyzed direct arylation of benzothiazoles I has also been disclosed. The utility of the developed protocol has been demonstrated by the synthesis of anti-tumor agents II, PMX-610 and CJM-126 (precursor). In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Reference of 5460-32-2).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Reference of 5460-32-2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com