New methods of imidazole functionalization – from imidazole to marine alkaloids was written by Du, Hongwang;He, Yong;Rasapalli, Sivappa;Lovely, Carl J.. And the article was included in Synlett in 2006.Application In Synthesis of 4,5-Diiodo-1H-imidazole This article mentions the following:
The pyrrole-imidazole family of marine alkaloids, the so-called oroidin natural products, exhibits an impressive diversity of structural motifs. The majority of these natural products contain one or more imidazole moieties intricately embedded within a polycyclic framework and thus present significant challenges to extant synthetic methods. Our approach to this problem has centered on the development of methods for the elaboration of simple imidazoles. This review describes the results of these efforts leading to the development of a variety of methods, including cycloadditions, oxidative and transition-metal-catalyzed reactions (e.g., with π-allylpalladium). In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Application In Synthesis of 4,5-Diiodo-1H-imidazole).
4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Application In Synthesis of 4,5-Diiodo-1H-imidazole
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com