Month: December 2022

Valente, Sergio published the artcile1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells, Application of 4-Iodobenzohydrazide, the publication is Journal of Medicinal Chemistry (2014), 57(14), 6259-6265, database is CAplus and MEDLINE.

We describe 1,3,4-oxadiazole-containing hydroxamates and 2-aminoanilides as histone deacetylase inhibitors. Among them, N-hydroxy-3-(4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)phenyl) acrylamide (1), N-hydroxy-4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)benzamide (2), and N-(2-aminophenyl)-4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)benzamide (3) were the most potent and selective against HDAC1. In U937 leukemia cells, (1) was more potent than vorinostat (SAHA) in inducing apoptosis, and (3) displayed cell differentiation with a potency similar to MS-275. In several acute myeloid leukemia (AML) cell lines, as well as in U937 cells in combination with doxorubicin, (3) showed higher antiproliferative effects than SAHA.

Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C14H10N2O, Application of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mendoza, Manuel published the artcileIndolactam dipeptides as nanomolar Gli inhibitors, Recommanded Product: 1-Iodohexane, the publication is ACS Medicinal Chemistry Letters (2022), 13(7), 1036-1042, database is CAplus and MEDLINE.

The Gli transcription factors within the Hedgehog (Hh) signaling pathway play essential roles in human development. However, the reactivation of Gli proteins in adult tissue is tumorigenic and drives the progression of several cancers, including the majority of basal cell carcinomas. Here we describe a novel set of indolactam dipeptides that target protein kinase C (PKC), exploiting the unique capacity of PKC isoenzymes to act as regulators of Gli. We devised an efficient synthetic route for the indolactam-based natural product (-)-pendolmycin and a series of analogs, and we evaluated these analogs in mechanistically distinct Gli reporter assays. The lead compound from these studies, N-hexylindolactam V (I), exhibits superior Gli suppression relative to clin. inhibitors and blocks the growth of Gli-dependent basal cell carcinoma cells. More broadly, our structure-activity studies provide inroads for the development of novel Gli antagonists and new avenues for combating Gli-driven cancers.

ACS Medicinal Chemistry Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rousseau, Lidie published the artcileRelevance of Single-Transmetalated Resting States in Iron-Mediated Cross-Couplings: Unexpected Role of σ-Donating Additives, Application In Synthesis of 638-45-9, the publication is Inorganic Chemistry (2021), 60(11), 7991-7997, database is CAplus and MEDLINE.

Control of the transmetalation degree of organoiron(II) species is a critical parameter in numerous Fe-catalyzed cross-couplings to ensure the success of the process. In this report, we however demonstrate that the selective formation of a monotransmetalated Fe^II species during the catalytic regime counterintuitively does not alone ensure an efficient suppression of the nucleophile homocoupling side reaction. It is conversely shown that a fine control of the transmetalation degree of the transient Fe^III intermediates obtained after the activation of alkyl electrophiles by a single-electron transfer (SET), achievable using σ-donating additives, accounts for the selectivity of the cross-coupling pathway. This report shows for the first time that both coordination spheres of Fe^II resting states and Fe^III short-lived intermediates must be efficiently tuned during the catalytic regime to ensure high coupling selectivities.

Inorganic Chemistry published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Application In Synthesis of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shigemitsu, Yasuhiro published the artcileDevelopment of novel functional dye using computed-aided molecular design techniques and its application to reagents for clinical test, etc., Product Details of C12H14IN, the publication is Nagasaki-ken Kogyo Gijutsu Senta Kenkyu Hokoku (2001), 23-33, database is CAplus.

Novel functional cyanine/merocyanine dyes were synthesized using versatile reactivity of nucleophilic reagents, ketenedithioacetals and 4-methylthiomaleimides. Quantum chem. calculations based on the MO method were carried out for light absorption anal. of these dyes. Also, absorption spectra of photochromic spirooxazine compounds showing absorptions in the longer wavelength region were theor. analyzed aiming at the mol. design of new photochromic compounds

Nagasaki-ken Kogyo Gijutsu Senta Kenkyu Hokoku published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C14H10O4, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zingaro, Ralph A. published the artcileInfrared spectra of pyridine coördinated iodine(I) salts, Recommanded Product: Pyridine Iodochloride complex, the publication is Journal of the American Chemical Society (1959), 1353-7, database is CAplus.

The spectra of (Ipy)X (py = C₅H₅N and X = OAc, BzO, CN, F, Cl, Br, ClO₄, and NO₃), (Ipy₂)ClO₄ and NO₃, and (pyH)I are determined and compared with those of py and solutions of I₂ in py. The results are related to data from studies of ultraviolet spectra and conductivities of I₂-py solutions The py-I₂ complex must be very polar. On the basis of the spectral change resulting from coördination of py with I₂ it is suggested that the 990-cm.^-1 band of py be assigned to a H deformation mode. (Ipy)CN is prepared by adding I₂ to AgCN suspended in a CHCl₃ solution of py. AgI and AgCN are separated and the filtrate evaporated at 1 mm. Hg and Dry-Ice temperature The compound forms orange crystals which can be kept as long as 10 days in vacuo at Dry-Ice temperature Decomposition begins at 34° and is rapid at 50-3°. It is colored only in nonpolar solvents. (Ipy)F is prepared similarly from AgF. It forms pale yellow crystals which decompose over the range 80-97°. It is soluble in EtOH and Me₂O with subsequent decomposition It is insoluble in CCl₄, CHCl₃, or CS₂. Decomposition is instantaneous on contact with water.

Journal of the American Chemical Society published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sheinker, V. N. published the artcileStudy of the structure and properties of heterocyclic compounds and their complexes. XXXIII. Charge transfer complexes of bromine iodide and chlorine iodide with azoles, Name: Pyridine Iodochloride complex, the publication is Zhurnal Obshchei Khimii (1976), 46(11), 2576-9, database is CAplus.

UV and dipole moment data were given for complexes of imidazoles, pyrazoles, thiazoles, oxazoles, and isoxazoles with ClI and BrI. The stability of the BrI complexes was lower than that of the ClI complexes, but both types were more stable than the analogous I2 complexes. The change of the dipole moment on complexation, the degree of charge transfer, and the stability constant all increased as the basicity of the azole increased.

Zhurnal Obshchei Khimii published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C20H12N2O2, Name: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kadiyala, Raghu Ram published the artcileComputed CH acidity of biaryl compounds and their deprotonative metalation by using a mixed lithium/zinc-TMP base, Synthetic Route of 1331850-50-0, the publication is Chemistry – A European Journal (2013), 19(24), 7944-7960, database is CAplus and MEDLINE.

A number of substituted biaryls, arylpyridines, arylpyrimidines and arylquinolines was prepared by coupling reactions; deprotonation-iodination with a mixed lithium/zinc-TMP base gives the corresponding iodides. The obtained exptl. results on acidity are compared with calculated values of Gibbs energies of deprotonation at different positions of the considered biaryl and arylheterocyclic systems. With the aim of synthesizing biaryl compounds, several aromatic iodides were prepared by the deprotonative metalation of methoxybenzenes, 3-substituted naphthalenes, isoquinoline, and methoxypyridines by using a mixed lithium/zinc-TMP (TMP = 2,2,6,6-tetramethylpiperidino) base and subsequent iodolysis. The halides thus obtained, as well as com. compounds, were cross-coupled under palladium catalysis (e.g., Suzuki coupling with 2,4-dimethoxy-5-pyrimidylboronic acid) to afford various representative biaryl compounds Deprotometalation of the latter compounds was performed by using the lithium/zinc-TMP base and evaluated by subsequent iodolysis. The outcome of these reactions has been discussed in light of the CH acidities of these substrates, as determined in THF solution by using the DFT B3LYP method. Except for in the presence of decidedly lower pK_a values, the regioselectivities of the deprotometalation reactions tend to be governed by nearby coordinating atoms rather than by site acidities. In particular, azine and diazine nitrogen atoms have been shown to be efficient in inducing the reactions with the lithium/zinc-TMP base at adjacent sites (e.g., by using 1-(2-methoxyphenyl)isoquinoline, 4-(2,5-dimethoxyphenyl)-3-methoxypyridine, or 5-(2,5-dimethoxyphenyl)-2,4-dimethoxypyrimidine as the substrate), a behavior that has already been observed upon treatment with lithium amides under kinetic conditions. Finally, the iodinated biaryl derivatives were involved in palladium-catalyzed reactions.

Chemistry – A European Journal published new progress about 1331850-50-0. 1331850-50-0 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Ether,Pyridine, name is 4-Iodo-3-methoxypyridine, and the molecular formula is C6H6INO, Synthetic Route of 1331850-50-0.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chen, Linfeng published the artcileNovel Colorimetric Method for Simultaneous Detection and Identification of Multimetal Ions in Water: Sensitivity, Selectivity, and Recognition Mechanism, Quality Control of 606-55-3, the publication is ACS Omega (2019), 4(3), 5915-5922, database is CAplus and MEDLINE.

Accurate recognition and speciation anal. of heavy metal ions in complex hydrol. environments is always a serious challenge. Here, we propose a small mol. based ultrasensitive colorimetric detection strategy, and apply to the accurate detection of Fe²⁺, Fe³⁺, Co²⁺ and Hg²⁺ in groundwater through the specific recognition of multiple ligands for different metals. The detection limits for Hg²⁺, Co²⁺, Fe²⁺ and Fe³⁺ are calculated as 6.51, 0.34, 0.49 and 1.01 ppb, resp., which are far below the drinking water standards and superior to most of the reported colorimetric sensors. The speciation anal. of Fe²⁺/Fe³⁺ also was realized by a 1-step method without complex pretreatment. The speciation and concentration of Fe²⁺ and Fe³⁺ in actual water samples can be accurately identified and monitored. For a visual on-site detection, we developed a simple test strip and applied to visual monitoring of 4 metals with the detection limit estimated by the naked eye as low as ppb-levels. This colorimetric method realizes the rapid, sensitive and portable multiple metal recognition and Fe²⁺/Fe³⁺ speciation anal., displaying great potential for on-site rapid water quality anal.

ACS Omega published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Quality Control of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Takale, Balaram S. published the artcileMild and Robust Stille Reactions in Water using Parts Per Million Levels of a Triphenylphosphine-Based Palladacycle, Synthetic Route of 602303-26-4, the publication is Angewandte Chemie, International Edition (2021), 60(8), 4158-4163, database is CAplus and MEDLINE.

An inexpensive and new triphenylphosphine-based palladacycle has been developed as a pre-catalyst, leading to highly effective Stille cross-coupling reactions in water under mild reaction conditions. Only 500-1000 ppm of Pd suffices for couplings involving a variety of aryl/heteroaryl halides with aryl/hetaryl stannanes. Several drug intermediates can be prepared using this catalyst in aqueous nanoreactors formed by 2 wt % Brij-30 in water.

Angewandte Chemie, International Edition published new progress about 602303-26-4. 602303-26-4 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 7-Chloro-2-iodothieno[3,2-b]pyridine, and the molecular formula is C8H15ClN2, Synthetic Route of 602303-26-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Since, Marc published the artcileOriginal TDAE strategy using α-halocarbonyl derivatives, Name: Ethyl 2-Iodopropionate, the publication is Tetrahedron (2009), 65(31), 6128-6134, database is CAplus.

The selective C-C bond formation by the reaction of nitrobenzyl carbanions, formed via the TDAE strategy, with α-haloesters and α-haloamides is disclosed. This reaction, extended in benzodioxole and dimethoxybenzene series provides new potentially CNS active agents.

Tetrahedron published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C15H21BO2, Name: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com