Month: December 2022

Bagrov, F. V. published the artcile2-Diphenylphosphinoyloxybenzaldehyde 4-Nitrophenyl-, 4-Phenyl-1-phthalazinyl-, and Aroylhydrazones and Thiosemicarbazone, Application In Synthesis of 39115-95-2, the publication is Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) (2002), 38(9), 1309-1313, database is CAplus.

Condensation of aryl- and aroylhydrazines and thiosemicarbazide with 2-diphenylphosphinoyloxybenzaldehyde results in formation of the corresponding hydrazones and thiosemicarbazone. The products give rise to conformational equilibrium between rotational and Z,E isomers, which is strongly displaced toward the E,E’,Z” isomer and is determined by the nature of substituent in the hydrazine fragment.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

De Bie, Dick A. published the artcilePhotoreactivity of diazines. III. Pyrimidines. XXXVIII. Photoamination of halopyrimidines, Quality Control of 41270-96-6, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1974), 1363-5, database is CAplus.

4-Amino-6-phenylpyrimidine was prepared by uv-induced amination of 4-halo-6-phenylpyrimidines in liquid NH3. A pyrimidinyl radical was formed by cleavage of C-halogen bonds. The order of reactivity was I > Br > Cl. 4-Phenylpyrimidine was also formed from the iodo and bromo compounds

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Quality Control of 41270-96-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

De Valk, J. published the artcilePyrimidines from this laboratory. XXXI. ANRORC [addition nucleophile ring opening ring closing] mechanism. V. Occurrence of the ANRORC [addition nucleophile ring opening ring closing] mechanism in aminations of substituted haloaza-aromatics with potassium amide in liquid ammonia, Formula: C10H7IN2, the publication is Recueil des Travaux Chimiques des Pays-Bas (1973), 92(3), 442-8, database is CAplus.

Evidence is presented that the amination of 4-chloro-2,6-diphenylpyrimidine with KNH2 in liquid ammonia into the corresponding 4-amino compound occurs to the extent of about 45% by the ANRORC mechanism. In the amination of the 4-iodo- and 4-fluoro derivatives of 2,6-diphenylpyrimidine however, the ANRORC mechanism is not operative at all. The amination of 5-bromo-4-chloro-2,6-diphenylpyrimidine into 4-amino-5-bromo-2,6-diphenylpyrimidine occurs to the extent of about 18% by the ANRORC mechanism. The synthesis of 5-bromo-4-chloro-2,6-diphenylpyrimidine-1(3)-15N and of the 4-fluoro, 4-chloro and 4-iodo derivatives of 2,6-diphenylpyrimidine-1(3)-15N is described.

Recueil des Travaux Chimiques des Pays-Bas published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Formula: C10H7IN2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ghisaidoobe, Amar T. published the artcileIdentification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors, Recommanded Product: 5-Bromo-2-iodobenzotrifluoride, the publication is Journal of Medicinal Chemistry (2014), 57(21), 9096-9104, database is CAplus and MEDLINE.

This work details the evaluation of a number of N-alkylated deoxynojirimycin derivatives on their merits as dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. Building on the previous work, the authors synthesized a series of D-gluco and L-ido-configured iminosugars N-modified with a variety of hydrophobic functional groups. The authors found that iminosugars featuring N-pentyloxymethylaryl substituents are considerably more potent inhibitors of glucosylceramide synthase than their aliphatic counterparts. In a next optimization round, the authors explored a series of biphenyl-substituted iminosugars of both configurations (D-gluco and L-ido) with the aim to introduce structural features known to confer metabolic stability to drug-like mols. From these series, two sets of mols. emerge as lead series for further profiling. Biphenyl-substituted L-ido-configured deoxynojirimycin derivatives are selective for glucosylceramidase and the nonlysosomal glucosylceramidase, and the authors consider these as leads for the treatment of neuropathol. lysosomal storage disorders. Their D-gluco-counterparts are also potent inhibitors of intestinal glycosidases, and because of this characteristic, the authors regard these as the prime candidates for type 2 diabetes therapeutics.

Journal of Medicinal Chemistry published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C7H3BrF3I, Recommanded Product: 5-Bromo-2-iodobenzotrifluoride.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Charistos, D. A. published the artcileSynthesis and UV and IR spectral study of some 2-aryl-Δ²-1,3,4-oxadiazoline-5-thiones, Formula: C7H7IN2O, the publication is Journal of Heterocyclic Chemistry (1994), 31(6), 1593-8, database is CAplus.

Twenty four 2-aryl-Δ²-1,3,4-oxadizoline-5-thiones (2) were synthesized and their UV and IR spectra were studied. Correlation between σ-Hammett constants of the aryl substituents and the differences in absorption maxima (Δν = ν₁-ν₂ in kK) of the electronic spectra of the deprotonated species were also evaluated. A new method for the synthesis of 2 (aryl = o-, m-, or p-aminophenyl) is also reported.

Journal of Heterocyclic Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ohwada, Jun published the artcileSynthesis and structure-activity relationships of a novel antifungal agent, azoxybacilin, Formula: C13H24INO4, the publication is Chemical & Pharmaceutical Bulletin (1994), 42(8), 1703-5, database is CAplus and MEDLINE.

A new antifungal substance, azoxybacilin (I; R = OH), an unusual amino acid with an azoxy moiety and its derivatives were prepared from Boc-Asp-OCMe₃ utilizing the Moss procedure for the preparation of the azoxy moiety. The ester derivative I (R = OCH₂Ph), Ro 09-1824, showed more potent antifungal activity and a broader antifungal spectrum than azoxybacilin did.

Chemical & Pharmaceutical Bulletin published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Formula: C13H24INO4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xanthopoulos, C. E. published the artcileStructural properties and potential reactivity of substituted 3-aroyldithiocarbazates, Formula: C7H7IN2O, the publication is Structural Chemistry (1994), 5(3), 147-54, database is CAplus.

The substituted 3-aroyldithiocarbazates I (X = H, halo, nitro, alkyl, etc.) were prepared The corresponding acid dissociation constants were determined potentiometrically. Semiempirical PM3 MO calculations suggest the existence of several tautomeric forms of the compounds Geometrical parameters, proton affinities, and static reactivity indexes have been examined Structural properties and protonation sites are well described by calculations The strong correlations between the pK_a values and the Hammett σ constants as well as the N(3) calculated proton affinities indicate that the N(3) atom is the most probable protonation site. The thermodn. of the protonation process are mainly controlled by HOMO-LUMO rather than electrostatic interactions. According to PM3 results, 3-aroyldithiocarbazic acid should be quite stable in the gas phase, while a mechanism for its decomposition in solution is proposed.

Structural Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C5H6BNO2, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lightfoot, Andrew P. published the artcileOn the mechanism and origin of the stereoselectivity in iodo-deboronation and chloro-deboronation of hindered alkenyl boronate esters using either ICl-NaOMe or ICl-pyridine, Product Details of C5H5ClIN, the publication is Tetrahedron Letters (2004), 45(46), 8557-8561, database is CAplus.

Conversion of hindered alkenyl boronate esters into the corresponding iodoalkene, or alkenyl chloride can be carried out stereoselectively using ICl. In the presence of NaOMe, direct reaction of ICl is favored yielding the E-iodoalkene, however, the reaction with ICl followed by NaOMe can be used to give different major alkenyl iodide and chloride products, depending upon reaction temperature, ICl source and alkenyl boronate stereoelectronics.

Tetrahedron Letters published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Product Details of C5H5ClIN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kashin, A. N. published the artcileReactivity of organotin compounds. XXVII. New method for the activation of organotin compounds in electrophilic substitution reactions. Study of the reaction kinetics of α-stannylated esters with iodine in the presence of triorganoiodostannanes, Synthetic Route of 31253-08-4, the publication is Zhurnal Organicheskoi Khimii (1984), 20(8), 1611-20, database is CAplus.

The kinetics of the reactions of R₃SnCHR¹CO₂R² (R = Me, Et, Bu; R¹ = H, Me, Ph; R² = Me, Et, Me₂CH, Me₃C) with iodine in DMF containing KI was studied. The reaction is autocatalytic with formation of R₃SnI, and the final product is ICHR¹CO₂R². In the presence of excess R₃SnI the reaction is 2nd order overall, 1st order in each reactant, and its rate is not dependent on the KI and R₃SnI concentrations

Zhurnal Organicheskoi Khimii published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Synthetic Route of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tornero, J. D. published the artcileMixed halide complexes of tin(IV) with pyridine, Recommanded Product: Pyridine Iodochloride complex, the publication is Anales de Quimica, Serie B: Quimica Inorganica y Quimica Analitica (1986), 82(2), 145-9, database is CAplus.

By oxidative-addition reactions of X₂ (X = Br, I) and XI.py (X = Cl, Br) to SnCl₂ in the presence of pyridine, SnCl₂X₂py₂ (X = Br, I), SnCl₃Ipy₂ and SnCl₂BrIpy₂ were obtained and studied by vibrational and ¹¹⁹Sn Moessbauer spectroscopy. A C_2v symmetry, with the ligands in trans positions, was proposed for SnCl₂Br₂py₂, whereas Moessbauer spectra of the remaining species show the presence of some impurities. A linear regression between the position of some pyridine bands in the IR spectra and the average electronegativity of halogens was observed, the υ₄ frequency being the most sensitive with respect to the metal-ligand bond strength.

Anales de Quimica, Serie B: Quimica Inorganica y Quimica Analitica published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C3H5BN2O2, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com