Month: December 2022

Hu, Yun-Xia published the artcileSynthesis, crystal structures, and photoluminescence of two novel zinc coordination polymers built from 2,2′-(ethyne-1,2-diyl)diterephthalate, Quality Control of 165534-79-2, the publication is Inorganic Chemistry Communications (2012), 173-176, database is CAplus.

Two coordination polymers, [Zn(EDDT)_0.5(H₂O)₂] (1) and [Zn(EDDT)_0.5(BPE)]·xG (2) (EDDT = 2,2′-(ethyne-1,2-diyl)diterephthalate, BPE = 1,2-bi(4-pyridyl)ethane, G = guest mol.), were solvothermally synthesized from the rigid planar linker of EDDT and the coligand of BPE, resp., in which complex 1 displays 2-dimensional [Zn(EDDT)_0.5] coordination layer, and the resulting 3-dimensional supramol. network is formed via interlayer H-bonding interactions, whereas complex 2 exhibits an intriguing microporous framework via the coordination of auxiliary ligand BPE. Both of them show enhanced strong blue luminescence.

Inorganic Chemistry Communications published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Quality Control of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tian, Zhenhao published the artcile“Domain Directional Optimization” strategy for the development of UGT1A1-activated fluorescent probe and the application in living systems, Application In Synthesis of 638-45-9, the publication is Sensors and Actuators, B: Chemical (2022), 132342, database is CAplus.

Activity-based fluorescent probes have emerged as the powerful tool for directly monitoring enzyme activity in living systems. Whereas, constructing high isoform-specific fluorescent probes for a target isoenzyme with multiple subtypes is still facing challenge. UGT1A1, as an isoform of UGTs, is a clear target for neonatal jaundice, irinotecan-induced toxicity, and fatal Crigler-Najjar syndrome type I. Herein, a “Domain Directional Optimization” strategy was proposed based on the systematic computational chem. and synchronously exptl. verification. Finally, an isoform-specific “switch-on” fluorescent probe (BUHE) was developed for UGT1A1 based on the boron-dipyrromethene (BODIPY) skeleton. BUHE exhibited the high selectivity and sensitivity toward UGT1A1 and the catalytic progress followed typical Michaelis-Menten kinetic. Moreover, BUHE had a good biocompatibility and chem. stability which was successfully applied to the activity evaluation and in situ imaging of UGT1A1 in complicated bio-systems including living cells, tissue slices and whole organs. In summary, the “Domain Directional Optimization” strategy could serve as a powerful method for developing the isoform-specific fluorescent probe.

Sensors and Actuators, B: Chemical published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C4H6O3, Application In Synthesis of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dong, Zhe published the artcileSimple Amine-Directed Meta-Selective C-H Arylation via Pd/Norbornene Catalysis, Quality Control of 165534-79-2, the publication is Journal of the American Chemical Society (2015), 137(18), 5887-5890, database is CAplus and MEDLINE.

Herein we report a highly meta-selective C-H arylation using simple tertiary amines as the directing group. This method takes advantage of Pd/norbornene catalysis, offering a distinct strategy to control the site selectivity. The reaction was promoted by com. available AsPh₃ as the ligand and a unique “acetate cocktail”. Aryl iodides with an ortho electron-withdrawing group were employed as the coupling partner. A wide range of functional groups, including some heteroarenes, are tolerated under the reaction conditions. In addition, the amine directing group can be easily installed and transformed to other common versatile functional groups. We expect this C-H functionalization mode to have broad implications for developing other meta-selective transformations beyond this work.

Journal of the American Chemical Society published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Quality Control of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xiao, Yufeng published the artcileDiscovery of histone deacetylase 3 (HDAC3)-specific PROTACs, Synthetic Route of 39115-95-2, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(68), 9866-9869, database is CAplus and MEDLINE.

Histone deacetylases (HDACs) are validated drug targets for cancer treatment. Increased HDAC isoenzyme selectivity and novel strategies to inhibit HDAC activity could lead to safer and more effective drug candidates. Nonetheless, it is quite challenging to develop isoenzyme-specific HDACi due to the highly conserved catalytic domain. We discovered XZ9002, a first-in-class HDAC3-specific PROTAC that potently degraded HDAC3. Importantly, XZ9002 is more effective to inhibit cancer cell proliferation than its proteolysis-inactive counterpart, suggesting HDAC3 degradation is a novel and promising anticancer approach.

Chemical Communications (Cambridge, United Kingdom) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C4H3Cl2N3, Synthetic Route of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Boerdalen, Bjoern E. published the artcileOsmotic properties of some contrast media, Safety of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, the publication is Investigative Radiology (1970), 5(6), 559-65, database is CAplus and MEDLINE.

The contrast media, when compared on the basis of I concentration, showed only minor differences in osmolality and water activity when calculated from concentrations and osmotic coefficients A plot of osmolality vs. I concentration for different contrast media showed a slightly curved line with Angio-Conray at the top and isopaque 260 at the bottom. The mols. of some of the contrast media deviated from the theoretically assumed spherical sym.

Investigative Radiology published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Safety of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chen, Chen published the artcilePhoto-selective chain end transformation of polyacrylate-iodide using cysteamine and its application to facile single-step preparation of patterned polymer brushes, Application In Synthesis of 31253-08-4, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(97), 13738-13741, database is CAplus and MEDLINE.

Cysteamine, which is an inexpensive and non-toxic aminothiol, was successfully employed as a photo-selective chain end transformation agent of iodo-terminated polymer chains (polymer-I). Polymer-I was selectively transformed to hydrogen-terminated (polymer-H) and thiol-terminated (polymer-SH) polymers with and without UV irradiation, resp. This method is applicable to acrylate polymers. This photo-selective reaction offered a single-step preparation of patterned polymer brushes with SH and H chain end functionalities as a unique application.

Chemical Communications (Cambridge, United Kingdom) published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application In Synthesis of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Takaishi, Tomohiro published the artcileMultigram-scale and column chromatography-free synthesis of L-azetidine-2-carboxylic acid for the synthesis of nicotianamine and its derivatives, SDS of cas: 161370-66-7, the publication is Heterocycles (2018), 96(12), 2126-2134, database is CAplus.

Multigram-scale synthesis of L-azetidine-2-carboxylic acid from L-aspartic acid was achieved in 13 conventional synthetic steps, without the need for purification by silica-gel column chromatog. and expensive reagents. Nicotianamine and its fluorescence-labeled derivatives could be obtained from this synthetic strategy.

Heterocycles published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C8H15NO, SDS of cas: 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kusakabe, Yu published the artcileImidazole Acceptor for Both Vacuum-Processable and Solution-Processable Efficient Blue Thermally Activated Delayed Fluorescence, Computed Properties of 364-12-5, the publication is ACS Omega (2022), 7(19), 16740-16745, database is CAplus and MEDLINE.

The members of the imidazole family have been widely used for electron transporting, host, conventional fluorescent, and phosphorescent materials. Although the imidazole core also has great potential as an acceptor segment of deep-blue thermally activated delayed fluorescence (TADF) owing to its high triplet energy, the emission color of imidazole-based TADF organic light-emitting diodes (OLEDs) has so far been limited to blue to green. In this work, four acridan-imidazole systems are theor. designed aiming for deep- or pure-blue emitters. All four emitters exhibit deep-blue to blue emission owing to the high energy levels of the lowest excited singlet states, exhibiting y coordinates of Commission Internationale de l’Eclairage coordinates between 0.06 and 0.26. The mol. composed of a trifluoromethyl-substituted benzimidazole acceptor in combination with a tetramethyl-9,10-dihydroacridine donor (named MAc-FBI) achieves a high maximum external quantum efficiency (EQE_MAX) of 13.7% in its application to vacuum-processed OLEDs. The emitter has high solubility even in ecofriendly nonhalogenated solvents, which motivates us to fabricate solution-processed MAc-FBI-based OLEDs, resulting in an even higher EQE_MAX of 16.1%.

ACS Omega published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C7H3BrF3I, Computed Properties of 364-12-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Khansole, Sandeep V. published the artcileKinetics of iodination of aniline and substituted anilines by pyridinium iodochloride in methanol, Recommanded Product: Pyridine Iodochloride complex, the publication is Physical Chemistry: An Indian Journal (2007), 2(3), 167-170, database is CAplus.

The kinetics of iodination of the aniline and substituted anilines using pyridinium iodochloride in methanol has been studied under varying conditions. The rates shows first order kinetics each in pyridinium iodochloride and anilines. The rates of reactions are measured at different temperature and activation parameters for all amines computed. Hammett plot is found to be valid and the correlation between the enthalpies and free energies of activations is reasonably linear with an isokinetic temperature 347 K. Similarly log A values of all the amines are optimized corresponding to Ea of amines through the equation, log A = logk_obs + Ea/2.303RT.

Physical Chemistry: An Indian Journal published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Verma, Supriy published the artcileDrastic influence of amide functionality and alkyl chain length dependent physical, thermal and structural properties of new pyridinium-amide cation based biodegradable room temperature ionic liquids, Product Details of C6H13I, the publication is Journal of Molecular Structure (2022), 1250(Part_1), 131679, database is CAplus.

A series of new room-temperature ionic liquids (RTILs) based on biodegradable pyridinium carboxamide cation and conformationally flexible NTf₂ anion have been synthesized. The variation of thermo-phys. properties of these RTILs with alkyl chain length size has been studied and compared with corresponding parental pyridinium NTf₂ ILs. A drastic change in thermophys. properties has been noted on the introduction of the amide functionality on pyridinium cation moiety. The crucial role of amide functionality is also important concerning biodegradability as it acts as an active site for an enzymic attack, helpful toward biodegradation Besides, the dependence of thermal and phys. properties on alkyl chain length is also noteworthy. A detailed DFT based theor. studies substantiate the exptl. observation of chain length dependence m.p. variation and successfully correlated that with stabilization energy. Conformational dynamics of NTf₂ anion (between transoid and cisoid) has been elucidated by Raman spectroscopic studies. Interestingly, the data demonstrate that the conformation of NTf₂ anion depends on the chain length of the cation, clearly indicating anionic interaction with the hydrophobic region of the cation. This information is crucial as it vindicates the fact that multiple weak interaction do exist in ILs making it a complex nanostructured system composed of ions.

Journal of Molecular Structure published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C7H6ClN3, Product Details of C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com