Month: December 2022

Roesch, Kevin R. published the artcileSynthesis of Isoquinolines and Pyridines by the Palladium-Catalyzed Iminoannulation of Internal Alkynes, Application In Synthesis of 165534-79-2, the publication is Journal of Organic Chemistry (2001), 66(24), 8042-8051, database is CAplus and MEDLINE.

A wide variety of substituted isoquinoline, tetrahydroisoquinoline, 5,6-dihydrobenz[f]isoquinoline, pyrindine, and pyridine heterocycles have been prepared in good to excellent yields via annulation of internal acetylenes with the tert-butylimines of o-iodobenzaldehydes and 3-halo-2-alkenals in the presence of a palladium catalyst. The best results are obtained by employing 5 mol % of Pd(OAc)₂, an excess of the alkyne, 1 equiv of Na₂CO₃ as a base, and 10 mol % of PPh₃ in DMF as the solvent. This annulation methodol. is particularly effective for aryl- or alkenyl-substituted alkynes. When electron-rich imines are employed, this chem. can be extended to alkyl-substituted alkynes. Trimethylsilyl-substituted alkynes also undergo this annulation process to afford monosubstituted heterocyclic products absent the silyl group.

Journal of Organic Chemistry published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Application In Synthesis of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Han, Jie published the artcileSynthesis and liquid crystalline properties of substituted 2,5-diaryl 1,3,4-oxadiazole derivatives without flexible chains, Recommanded Product: 4-Iodobenzohydrazide, the publication is Liquid Crystals (2008), 35(12), 1359-1365, database is CAplus.

A series of new compounds based on aromatically 2,5-disubstituted 1,3,4-oxadiazoles without flexible chains, formulated as p-R-C6H4-(OC2N2)-(p-C6H4)2-R’ with (i) R = CH3O, R’ = CH3O, CH3S, F, H (Ia-Id), (ii) R = CH3S, R’ = CH3O, CH3S, F, H (IIa-IId) and (iii) R = F, R’ = CH3O, CH3S, F, H (IIIa-IIId) (p-C6H4 and OC2N2 represent a p-phenylene spacer and a 1,3,4-oxadiazole ring, resp.), were synthesized and characterized by ¹H and ¹³C NMR, MS and HRMS techniques. Mesomorphic properties were investigated using differential scanning calorimetry and polarizing optical microscopy. All of the target compounds (except Id, IId, IIIc and IIId) exhibited an enantiotropic nematic mesophase with high melting temperatures The liquid crystalline properties of these compounds were influenced greatly by polarity, steric factors and positions of the terminal groups. The effect of the terminal groups on the liquid crystal properties is discussed.

Liquid Crystals published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Han, Xiaojing published the artcileA FRET-based ratiometric fluorescent probe to detect cysteine metabolism in mitochondria, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Organic & Biomolecular Chemistry (2020), 18(7), 1487-1492, database is CAplus and MEDLINE.

As an important biothiol in living cells, cysteine is closely related to oxidative damage in living organisms. Sulfite from cysteine metabolism in living cells plays a crucial role in maintaining homeostasis in an organism, and the unbalance of sulfite in vivo would lead to multiple diseases. Thus the development of a new fluorescent probe for cysteine metabolism is needed urgently in mitochondria which are the main place of cysteine metabolism Herein the authors construct a novel targeting mitochondria fluorescent probe CP-K (I) based on the FRET mechanism to visualize sulfite in living MCF-7 cells. Probe CP-K displays a large Stokes shift of 150 nm, a low detection limit (26.3 nM) and “naked eye” detection after the addition of HSO₃^–. Importantly, it is appropriate for imaging the endogenous sulfite from cysteine metabolism in living cells.

Organic & Biomolecular Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhou, Yu published the artcileGold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones, Name: (2-Amino-5-iodophenyl)methanol, the publication is Advanced Synthesis & Catalysis (2010), 352(2+3), 373-378, database is CAplus.

A highly efficient method has been developed for the one-pot synthesis of multiring heterocyclic compounds, e.g. I (R¹ = H, Ph, etc.; R² = H, Me; R³ = H, n-C₆H₁₃) and II (R⁴ = H, Cl, Ph, etc.) via a gold(I)-catalyzed tandem coupling/cyclization reaction of o-aminobenzyl alcs. with HCCCH₂CH(R³)CO₂H and HCC(CH₂)₃CO₂H, resp. The strategy presents a straightforward and efficient approach to construct novel tricyclic or polycyclic mol. architectures in which two new C-N bonds and one C-O bond are formed in a one-pot reaction operation from two simple starting materials. Moreover, a broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields.

Advanced Synthesis & Catalysis published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C3H3Br2ClO, Name: (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yokoyama, Takuya published the artcileIdentification of candidate molecular targets of the novel antineoplastic antimitotic NP-10, SDS of cas: 39115-95-2, the publication is Scientific Reports (2019), 9(1), 1-13, database is CAplus and MEDLINE.

We previously reported the identification of a novel antimitotic agent with carbazole and benzohydrazide structures: N’-[(9-ethyl-9H-carbazol-3-yl)methylene]-2-iodobenzohydrazide (code number NP-10). However, the mechanism(s) underlying the cancer cell-selective inhibition of mitotic progression by NP-10 remains unclear. Here, we identified NP-10-interacting proteins by affinity purification from HeLa cell lysates using NP-10-immobilized beads followed by mass spectrometry. The results showed that several mitosis-associated factors specifically bind to active NP-10, but not to an inactive NP-10 derivative Among them, NUP155 and importin β may be involved in NP-10-mediated mitotic arrest. Because NP-10 did not show antitumor activity in vivo in a previous study, we synthesized 19 NP-10 derivatives to identify more effective NP-10-related compounds HMI83-2, an NP-10-related compound with a Cl moiety, inhibited HCT116 cell tumor formation in nude mice without significant loss of body weight, suggesting that HMI83-2 is a promising lead compound for the development of novel antimitotic agents.

Scientific Reports published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C4H6O3, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ai, Han-Jun published the artcileRuthenium pincer complex-catalyzed heterocycle compatible alkoxycarbonylation of alkyl iodides: substrate keeps the catalyst active, Name: 1-Iodohexane, the publication is Chemical Science (2022), 13(8), 2481-2486, database is CAplus and MEDLINE.

In this work, a pincer ruthenium pincer complex-catalyzed heterocycle compatible alkoxycarbonylation of alkyl iodides using alcs. and carbon monoxide to afford esters I [R = iPr, tBu, Ph, etc.; R¹ = tBu, cyclopentyl, (CH₂)₃Ph, etc.] was reported. Benefitting from the pincer ligand, a variety of heterocycles, such as thiophenes, morpholine, unprotected indoles, pyrrole, pyridine, pyrimidine, furan, thiazole, pyrazole, benzothiadiazole, and triazole, were compatible in this protocol.

Chemical Science published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Name: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Long, Lingliang published the artcileConstruction of a fluorescent probe for selectively detecting singlet oxygen with a high sensitivity and large concentration range based on a two-step cascade sensing reaction, Application of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(58), 8462-8465, database is CAplus and MEDLINE.

A novel fluorescent probe XQ-1 for selectively detecting ¹O₂ on the basis of a two-step cascade reaction has been rationally constructed. The probe responded to ¹O₂ not only showing a high sensitivity, but also displaying a large concentration range, which means that the probe can be used as a powerful tool to monitor the efficacy of PDT toward cancer and concurrently track the adverse effects on healthy cells.

Chemical Communications (Cambridge, United Kingdom) published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sun, Li-Wen published the artcileTransition-metal-free hydroamination/defluorination/cyclization of perfluoroalkyl alkynes with amidines, Related Products of iodides-buliding-blocks, the publication is Organic Chemistry Frontiers (2022), 9(1), 109-116, database is CAplus.

An efficient defluorinative net-[3 + 3]-cyclization strategy for the construction of perfluoroalkyl-substituted pyrimidine derivatives by using a series of perfluoroalkyl alkynes and amidines as starting materials was developed. The present reaction proceeded successfully under transition-metal-free conditions to form two new C-N bonds and a new heterocyclic ring through a sequence of hydroamination, defluorination, and annulation. The desired pyrimidines could be obtained with good functional group tolerance and moderate to good yields. Moreover, the distinctive fluorine effects of perfluoroalkyl substituents are vital for tuning the reactivity of alkynes for the anticipated defluorinative annulation. The pendant π system would lower associated bond dissociation energy significantly compared to that of a nonactivated C(sp3)-F bond.

Organic Chemistry Frontiers published new progress about 134322-01-3. 134322-01-3 belongs to iodides-buliding-blocks, auxiliary class Salt,Iodide,Amine,Amidine,Benzene, name is 4-Iodobenzimidamide hydrochloride, and the molecular formula is C10H14O, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Xiao-Xu published the artcileNiH-catalyzed reductive hydrocarbonation of enol esters and ethers, Recommanded Product: 1-Iodohexane, the publication is CCS Chemistry (2022), 4(2), 605-615, database is CAplus.

Chiral dialkyl carbinols and their derivatives are significant synthetic building blocks in organic chem. and related fields. The development of convenient and efficient methods to access these compounds has long been an important endeavor. Herein, authors report a NiH-catalyzed reductive hydroalkylation and hydroarylation of enol esters and ethers. α-Oxoalkyl organonickel species were generated in situ in a catalytic mode and then participated in cross-coupling with alkyl or aryl halides. This approach enabled C(sp3)-C(sp3) and C(sp3)-C(sp2) bond formation under mild reductive conditions with simple operations, thereby boosting a broad substrate scope and good functional compatibility. Esters of enantioenriched dialkyl carbinols were accessed in a catalytic asym. version. Mechanistic studies demonstrated that this reaction proceeded through a syn-addition of Ni-H intermediate to an enol ester with high regio- and enantioselectivity.

CCS Chemistry published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C10H12F6N4O6PdS2, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com