Month: December 2022

Zhang, Yadong published the artcilePolymers with Carbazole-Oxadiazole Side Chains as Ambipolar Hosts for Phosphorescent Light-Emitting Diodes, Quality Control of 39115-95-2, the publication is Chemistry of Materials (2011), 23(17), 4002-4015, database is CAplus.

Polymethacrylates, polystyrenes, and polynorbornenes bearing 2-(3-(carbazol-9-yl)phenyl)-5-phenyl-1,3,4-oxadiazole, 2-(4-(carbazol-9-yl)phenyl)-5-phenyl-1,3,4-oxadiazole, 2-((3,5-di(carbazol-9-yl)phenyl)-5-phenyl-1,3,4-oxadiazole) groups linked to the polymer backbone through the 3-position of their terminal Ph groups have been synthesized for use as solution-processable ambipolar hosts for phosphorescent light-emitting diodes. The polymers exhibit good thermal stabilities, with no weight loss below 350 °C, and have glass-transition temperatures in the range 118-209°. Spectroscopic, electrochem., and quantum-chem. data for small-mol. model compounds suggest that the side chain groups are suitable hosts for a range of phosphors, including the green-emitter fac-tris(2-phenylpyridinato-N,C²‘)iridium (Ir(ppy)₃). Light-emitting diodes were fabricated, each with a solution-processed photo-cross-linked hole-transport layer, a solution-processed emissive layer composed of a carbazole-oxadiazole-functionalized polymethacrylate doped with Ir(ppy)₃, and an evaporated electron-transport layer. The polymer with 2-(3,5-(dicarbazol-9-yl)phenyl)-5-phenyl-1,3,4-oxadiazole units in the side chain exhibited the lowest turn-on voltage (6.0 V), and the highest efficiency (external quantum efficiency of 10.0%, current efficiency of 34.1 cd/A).

Chemistry of Materials published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C15H21BO3, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rajasekaran, Deepa published the artcileTargeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment, Application of 4-Iodo-6-phenylpyrimidine, the publication is FASEB Journal (2014), 28(11), 4961-4971, database is CAplus and MEDLINE.

We report a new inflammatory activity for extracellular D-dopachrome tautomerase (D-DT), the recruitment of neutrophils to the lung on D-DT intratracheal installation of C57BL/6J mice with an EC₅₀ of 5.6 μg. We also find that D-DT and macrophage migration inhibitory factor (MIF) have additive effects in neutrophil recruitment. Although the tautomerase site of D-DT and its homolog MIF are biophys. very different, 4-iodo-6-phenylpyrimidine (4-IPP) forms a covalent bond with Pro-1 of both proteins, resulting in a 6-phenylpyrimidine (6-PP) adduct. Recruitment of neutrophils to the lung for the 6-PP adducts of D-DT and MIF are reduced by ∼50% relative to the apo proteins, demonstrating that an unmodified Pro-1 is important for this activity, but there is no cooperativity in inhibition of the proteins together. The differences in the binding mode of the 6-PP adduct for D-DT was determined by crystallog. studies at 1.13 Å resolution and compared to the structure of the MIF-6-PP complex. There are major differences in the location of the 6-PP adduct to the D-DT and MIF active sites that provide insight into the lack of cooperativity by 4-IPP and into tuning the properties of the covalent inhibitors of D-DT and MIF that are necessary for the development of therapeutic small mols. against neutrophil damage from lung infections such as Pseudomonas aeruginosa in cystic fibrosis and immunocompromised patients.

FASEB Journal published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Application of 4-Iodo-6-phenylpyrimidine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhou, Fang published the artcileCatalytic Asymmetric Hydroalkylation of α,β-Unsaturated Amides Enabled by Regio-Reversed and Enantiodifferentiating syn-Hydronickellation, Formula: C6H13I, the publication is ACS Catalysis (2021), 11(14), 8766-8773, database is CAplus.

Here, an enantioselective nickel-hydride catalyzed hydroalkylation of readily accessible β-alkyl-α,β-unsaturated amides to form structurally diverse β-chiral amides e.g., I was reported. This process was proposed to proceed through an enantiodifferentiating syn-hydrometalation of nickel hydride, forming chiral alkylnickel at β-position in which regioselectivity is different than that with copper hydride. This regio-reversed hydronickellation process provided a complementary approach to access enantioenriched β-functionalization amides with a stereocenter at β-position.

ACS Catalysis published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C5H5F3O2, Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Renhe published the artcileDirect Vicinal Difunctionalization of Thiophenes Enabled by the Palladium/Norbornene Cooperative Catalysis, Synthetic Route of 165534-79-2, the publication is Journal of the American Chemical Society (2019), 141(48), 18958-18963, database is CAplus and MEDLINE.

Herein a direct vicinal difunctionalization of thiophenes via the palladium/norbornene (Pd/NBE) cooperative catalysis is reported. A series of mono- and disubstituted thiophenes can be difunctionalized site-selectively and regioselectively at the C4 and C5 positions in good yields, enabled by an arsine ligand and a unique amide-based NBE. The synthetic utility has been shown in derivatizations of complex bioactive compounds and an open-flask gram-scale preparation Preliminary results have been obtained in the difunctionalization of furans and a direct C4-selective arylation of 2-substituted thiophenes.

Journal of the American Chemical Society published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Synthetic Route of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jiang, Baifeng published the artcileOne-pot synthesis of dihydrobenzo[4,5][1,3]oxazino[2,3-a]isoquinolines via a silver(I)-catalyzed cascade approach, Application of (2-Amino-5-iodophenyl)methanol, the publication is Molecules (2013), 814-831, database is CAplus and MEDLINE.

An efficient approach for the synthesis of biol. interesting fused tetracyclic isoquinoline derivatives in high yield and with a broad substrate scope was developed. The strategy features an AgNO₃ catalyzed one-pot cascade process involving formation of two new C-N bonds and one new C-O bond. The title compounds thus formed included 12-phenyl-4bH,6H-isoquino[2,1-a][3,1]benzoxazine (I) and related substances, such as a pyridooxazinoisoquinoline derivative (II). The synthesis of the target compounds was achieved using 2-(2-phenylethynyl)benzaldehyde, 5-fluoro-2-(2-phenylethynyl)benzaldehyde, 2-(1-octyn-1-yl)benzaldehyde, 2-aminobenzenemethanol, 3-amino-2-naphthalenemethanol, 2-amino-3-pyridinemethanol (amino arenemethanol derivatives) as starting materials.

Molecules published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Application of (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Peng, Ye-Dong published the artcileFerrocene-isocoumarin conjugated molecules: synthesis, structural characterization, electronic properties, and DFT-TDDFT computational study, Related Products of iodides-buliding-blocks, the publication is Dalton Transactions (2015), 44(32), 14465-14474, database is CAplus and MEDLINE.

Two ferrocene-isocoumarin conjugated mols., Me 3-ferrocenyl-1-oxo-1H-isochromene-6-carboxylate (Fc-Icm) and 3,8-bisferrocenylpyrano[3,4-g]isochromene-1,6-dione (BFc–PIcm), were synthesized through the acid-prompted regioselective oxidative cyclization from di-Me 2-(ferrocenylethynyl)terephthalate (Fc-TP) and di-Me 2,5-bis(ferrocenylethynyl)terephthalate (BFc-TP), resp. Single-crystal x-ray diffraction, together with the d. functional theory (DFT) calculations, shows that the ferrocene-isocoumarin conjugated compounds display better coplanarity than the corresponding ferrocenylethynyl terephthalates. All the compounds exhibit characteristic MLCT, ICT and π-π^* transitions in the UV-visible range in solution, and Fc-Icm and BFc-PIcm show higher oscillator strength of the absorption than Fc-TP and BFc-TP, which are verified by time-dependent DFT (TDDFT) theor. calculations The electrochem. properties were studied by cyclic voltammetry (CV), which are also in accord with the theor. calculations

Dalton Transactions published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xiang, Jian-nan published the artcileSynthesis of diheterocyclic compounds on 1,3,4-oxadiazole and 1,2,4-triazole, Product Details of C7H7IN2O, the publication is Hunan Daxue Xuebao, Ziran Kexueban (2009), 36(3), 63-66, database is CAplus.

A method for the synthesis of the title compounds [i.e., 1,3,4-oxadiazole-2-thione and 1,2,4-triazole-3-thione derivatives] is reported here. Said compounds were prepared by a coupling reaction of (4-iodophenyl)(fluoroalkyl)-1,2,4-triazole-3-thione derivatives and (4-iodophenyl)(fluoroalkyl)-1,3,4-oxadiazole-2-thione derivatives with (ethynyl)(fluoroalkyl)-1,2,4-triazole-3-thione. This approach is based mol. design technol., such as activity substructure connection. Structures of the target compounds were determined by NMR, ¹⁹F-NMR, IR, MS, elemental anal.

Hunan Daxue Xuebao, Ziran Kexueban published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C39H35N5O8, Product Details of C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Han, Qian published the artcileA redox-switchable colorimetric probe for “Naked-Eye” detection of hypochlorous acid and glutathione, Synthetic Route of 606-55-3, the publication is Molecules (2019), 24(13), 2455, database is CAplus and MEDLINE.

We report the development of a new colorimetric probe (L-ol) for investigations of the redox process regulated by hypochlorous acid (HOCl) and glutathione (GSH). The HOCl/GSH redox-switching cycle process was investigated in detail by UV-visible absorption spectroscopy, colorimetric anal. assay and high-resolution mass spectrometry (HRMS). The switchable absorbance responses were attributed to the HOCl-induced oxidation of the p-methoxyphenol unit to the benzoquinone derivative (L-one) and sequential reduction of L-one to hydroquinone (L-ol’) by GSH. In phosphate-buffered saline (PBS) buffer, the absorbance of L-ol at 619 nm underwent a remarkable bathochromic-shift, accompanied by a color change from pale yellow to blue in the presence of HOCl. With further addition of GSH, the absorbance of L-one exclusively recovered to the original level. Meanwhile, the blue-colored solution returned to the naive pale yellow color in the presence of GSH. The detection limits for HOCl and GSH were calculated to be 6.3 and 96 nM according to the IUPAC criteria. Furthermore, L-ol-loaded chromatog. plates have been prepared and successfully applied to visualize and quant. analyze HOCl in several natural waters.

Molecules published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Synthetic Route of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xie, Li published the artcileDetermination of hypochlorite and bisulfite in water by bifunctional colorimetric sensor based on octupolar conjugated merocyanine dyes, Quality Control of 638-45-9, the publication is Microchemical Journal (2022), 172(Part_A), 106931, database is CAplus.

In this study, we developed a bifunctional colorimetric fluorescent sensor based on three merocyanine structures for the detection of hypochlorite (ClO^–) and bisulfite (HSO₃^–). In MeOH solution and under special conditions, this sensor shows high selectivity on fluorescence and UV-Vis spectra for the detection of ClO^– and HSO₃^–, resp. The sensor solution exhibits a strong red fluorescence emission at 638 nm, which was quenched and the blue color turned to purple pink rapidly upon the addition of ClO^–. The mechanism of the detection of ClO^– was confirmed via ESI-MS that the C=C groups were induced to produce ethylene oxide and ethylene glycol derivatives by hypochlorite. The fluorescence emission at 638 nm in the concentration range of ClO^– from 0 to 24 μM showed a good linear relationship (R² = 0.9919), and the LOD of the sensor for ClO^– was 0.42 μM. Interestingly, the sensor can also detect HSO₃^– in acid condition (pH less than 7.4). The blue shift of UV-Vis spectra of the solution of sensor were observed after addition of HSO₃^– and irradiation with visible light for about 4 min. The HSO₃^– concentration showed a good linear relationship (R² = 0.9987) at 275 nm in the range of 12-42 μM, and thus its LOD was calculated to be 1.14 μM. Finally, the sensor has important value for detecting ClO^– and HSO₃^– in tap water and lake water.

Microchemical Journal published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C9H5ClO2, Quality Control of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Linfeng published the artcileMicrowave-Assisted Nickel-Catalyzed Rapid Reductive Coupling of Ethyl 3-iodopropionate to Adipic Acid, Recommanded Product: 1-Iodohexane, the publication is Catalysis Letters (2021), 151(8), 2339-2345, database is CAplus.

3-Iodopropionic acid (3-IPA) can be efficiently synthesized from the glycerol derivative glyceric acid (GA), which is a potential biomaterial-based platform mol. In this report, Et 3-iodopropionate was rapidly dimerized to di-Et adipate in a microwave reactor using NiCl₂.6H₂O as a catalyst, co-catalyzed by Mn and the 1, 10-Phenanthroline monohydrate ligand. Under the optimum reaction conditions, di-Et adipate can be obtained with 84% yield at 90°C in just 5 min. Di-Et adipate was hydrolyzed to obtain the adipic acid (AA) in 89% yield with an acid catalyst. AA is an important chem. and a monomer for producing a wide range of high-performance polymeric substances. This rapid coupling method is also applicable to other alkyl halides.

Catalysis Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C18H12ClNO, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com