Month: December 2022

Gomaa, Maha Mobaruk published the artcileOxonium heterocyclic quinone in the synthesis of some cyanine dyes and their antimicrobial activity, Formula: C12H14IN, the publication is European Journal of Chemistry (2014), 5(3), 463-468, 6 pp., database is CAplus.

The motivation of the synthetic process of new heterocyclic cyanine dyes is to improve the specific characterization, photosensitization behavior, and probable application in the field of biol., medical science and physics. New heterocyclic compounds having oxonium nuclei were prepared and employed for the synthesis of some new photosensitizers cyanine dyes (monomethine, trimethine and styryl cyanines). The electronic visible absorption spectra of all the synthesized cyanines were investigated in 95% ethanol to attempt and throw some light on the influence of such new heterocyclic nuclei and to compare or evaluate spectral behaviors. Antimicrobial activity of selected compounds against some bacterial strains was tested. Structural identification was carried out via elemental anal., IR and ¹H NMR.

European Journal of Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Formula: C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bojarska-Dahlig, Halina published the artcile4-Pyridone-N-acetic acid and derivatives, Recommanded Product: 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, the publication is Roczniki Chemii (1955), 119-28, database is CAplus.

For pharmacol. investigations were prepared 4-pyridone-N-acetic acid (I) and some of its derivatives To 9.5 g. of 4-pyridone nitrate in 15 ml. H₂O and 8.88 g. NaOH was added 11.4 g. ClCH₂CO₂H (Ia) and the mixture refluxed 1 hr., then acidified with concentrated HCl, and kept 3 days to precipitate 7.2 g. I, m. 253-5° (from water). To 8.4 g. 3-nitro-4-pyridone (II) in 15 ml. H₂O and 11.4 g. NaOH was added 11.4 g. of Ia, the mixture refluxed 1 hr., and acidified with concentrated HCl to precipitate 8.9 g. 3-O₂N derivative (III) of I, m. 268-9°. III (4.95 g.) with 6.5 g. n-octyl alc. and 0.55 ml. H₂SO₄ in 15 ml. benzene boiled 2 hrs., 100 ml. H₂O added, the mixture neutralized with NaHCO₃, and the C₆H₆ distilled off to give 49% n-octyl ester of III, m. 135° (from 50% alc.). II (14 g.), 700 ml. 78% alc., 7 g. CaCl₂, 10 ml. H₂O, and 210 g. Zn dust refluxed 10 hrs., the mixture filtered, acidified with 10 ml. concentrated HCl, heated on a water bath until crystalline, and 20 ml. concentrated HCl added to yield 41% 3-amino-4-pyridone-2HCl (IV), m. 228-30° (from concentrated HCl). IV (4.48 g.), 20 ml. H₂O, 4.2 g. NaOH, and 2.82 g. Ia were heated 1 hr. on boiling water bath, concentrated HCl added to pH 5, and the mixture kept 10 hrs. to give 69.3% 3-H₂N derivative of I, dark colored crystals, m. 242-5° (from 50% alc.). To 7 g. II, 11.7 g. Na₂CO₃ hydrate, and 100 ml. H₂O at 50° was added dropwise 10.5 g. iodine and 10.5 g. KI in 100 ml. H₂O, the mixture heated 1 hr. at 50° and 2 hrs. 95-100°, saturated with SO₂ and kept 10 hrs. to give 58% 3-nitro-5-iodo-4-pyridone (V), yellow crystals, darken 270°, decompose 310° (from 50% alc.). To 16 g. V, 8.64 g. NaOH, and 20 ml. H₂O was added 11.4 g. Ia, the mixture heated on a water bath 1 hr., and acidified with concentrated HCl to give 87.6% 3-nitro-5-iodo-4-pyridone-N-acetic acid (VI), m. 252-4° (from H₂O); NH₄ salt (prepared in 25% NH₃), yellow needles, m. 225-8°; (HOCH₂CH₂)₂NH salt, m. 156-8° (from 90% alc.); Et ester, m. 122° (from 96% alc.); n-octyl ester, m. 105-7°. To 8.1 g. VI and 5.75 g. granulated Zn was gradually added 15 ml. concentrated HCl, the mixture heated 3 hrs. on boiling water bath, concentrated in vacuo to a sirup, 100 ml. H₂O added, and the solution saturated with H₂S, ZnS filtered off, and the filtrate concentrated on water bath to give the HCl salt (VII), m. 216-18° (from dilute HCl), of the 3-H₂N analog of VI. To 6.6 g. VII in 40 ml. 15% HCl was added with stirring during 10 min. 1.73 g. NaNO₂ in 5 ml. H₂O and the mixture kept 20 min. at 0° to give 94% N-carboxymethyl-5-iodo-4-pyridone-3-diazonium chloride, yellow crystals, m. 141-3°.

Roczniki Chemii published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Recommanded Product: 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bagrov, F. V. published the artcileCondensation of ethyl (ethoxymethylene)cyanoacetate with acyl- and diphenylphosphinylhydrazines, Related Products of iodides-buliding-blocks, the publication is Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) (2000), 70(3), 422-425, database is CAplus.

Condensation of Et (ethoxymethylene)cyanoacetate with hydrazides of diphenylphosphinic acid and aliphatic and aromatic acids in EtOH involves exclusively the ethoxymethylene group and yields the corresponding Et 3-oxo-2-cyanopropanoate hydrazones. These compounds exist in the crystalline state and in solutions as the enehydrazine tautomer in which the configurational equilibrium is determined by the nature of substituent in the hydrazine moiety.

Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bagrov, F. V. published the artcileReaction of ethyl ethoxymethyleneacetoacetate with hydrazine monoderivatives, Application of 4-Iodobenzohydrazide, the publication is Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) (2000), 36(2), 191-194, database is CAplus.

The reaction of Et α-ethoxymethyleneacetoacetate with acylhydrazines affords the corresponding acylhydrazones of α-formylacetoacetic ester. The ¹H NMR and IR spectra revealed that the compounds obtained existed in ketoenamine (ketoenhydrazine) form. The condensation of 4-chlorophenyl-, 4-nitrophenyl-, 6-chloropyridazinyl- and 4-phenylphthalazinylhydrazines with the Et ethoxymethyleneacetoacetate is accompanied by cyclization into the corresponding 5-methyl-4-ethoxycarbonylpyrazoles.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Al-Zahrani, Fatimah A. M. published the artcileSynthesis, Dynamics of Solvatochromism and pH-sensory of Novel Push-π-pull Phenothiazine-quinoline Fluorophore Toward Turn-on Fluorescent and Colorimetric Test Strips, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Fibers and Polymers (2022), 23(5), 1182-1189, database is CAplus.

Novel donor-central-π-bridge-acceptor (E)-1-ethyl-2-((10-hexyl-10H-phenothiazin-3-yl)methylene)-2,4a-dihydroquinolin-1-ium (PTZ-Q) fluorophore with remarkable solvatochromism, high fluorescence and pH-sensory properties was designed and synthesized in good yield. PTZ-Q sensor was fully characterized utilizing various spectroscopic techniques, including IR (FTIR), ¹H/¹³C NMR, and mass spectroscopic methods. UV-Vis absorption spectra of the prepared donor-acceptor PTZ-Q were explored in different solvents of varying polarities to show pos. solvatochromism related to intramol. charge transfer. Addnl., the fluorescence spectra of PTZ-Q displayed strongly solvent-dependent wavelength and band intensity. Stokes′ shifts were found to increase upon increasing the polarities of solvents up to 3984 cm^-1 for the highest polar solvents. Linear energy-solvation correlation was employed to examine solvent-dependent Stokes′ shift. Quantum yields () of PTZ-Q were determined The pH-dependent absorption and emission spectra in DMF were also explored. The UV-Vis absorption intensity was monitored at 522 nm, while the emission intensity was detected at 603 nm in DMF. The pH sensing mechanism was found to depend on proton abstraction to the PTZ-Q fluorophore to result in colorimetric and fluorescent spectral changes associated with a colorimetric shift from yellow to pink, red and purple. The synthesized PTZ-Q probe was utilized to fabricate colorimetric and fluorescent test strips with the ability to detect pH changes in aqueous media, which was verified with CIE Lab color coordinates.

Fibers and Polymers published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abu El-Hamd, Ragab M. published the artcileStudies on absorption spectra of newly synthesized cyanine dyes, Computed Properties of 606-55-3, the publication is Indian Journal of Heterocyclic Chemistry (1996), 5(4), 297-304, database is CAplus.

New asym. monomethine cyanines (I; R = H, Ph; X = NH, CH₂; A = H, C₄H₄; Z = H, C₄H₄), trimethine cyanines (II; X = NH, CH₂; A = H, C₄H₄; Z = H, C₄H₄), and styryl cyanines (III; R = H, OMe, NO₂; X = NH, CH₂; A = H, C₄H₄) were synthesized to study their spectral behavior, solvatochromism, mixed solvents and acid-base properties. These dyes are characterized by elemental anal., IR, ¹H NMR, and electronic absorption spectra.

Indian Journal of Heterocyclic Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abu El-Hamd, R. M. published the artcileSome new fused heterocyclic cyanine dyes with ring junction, Quality Control of 606-55-3, the publication is Chemical Papers (1997), 51(2), 117-127, database is CAplus.

New asym. pyrazolo[4′,5′:4,5]imidazo[3,2-a]/pyrrolo[1,2-a]pyridinium/quinolinium bromide iodide 1[4(1)]monomethine cyanines (I; R = H, Ph; A = 2 H, C₄H₄; X = CH₂, NH; Z = 2 H, C₄H₄), 1[2(4)]trimethine cyanines (II; A = 2 H, C₄H₄; X = CH₂, NH; Z = 2 H, C₄H₄) and/or 1-styryl cyanines (III; A = 2 H, C₄H₄; X = CH₂, NH; Y = H, p-OMe, p-NO₂) were synthesized to study their spectral behavior, solvatochromism, and acid-base properties. These dyes were characterized by elemental anal., IR, ¹H NMR, and electronic absorption spectra.

Chemical Papers published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Quality Control of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abd El-Aal, Reda Mahmoud published the artcileSynthesis and characterization of new photosensitizer bridgehead cyanine dyes, Synthetic Route of 606-55-3, the publication is Proceedings – Indian Academy of Sciences, Chemical Sciences (1999), 111(2), 343-352, database is CAplus.

Oxazolo[1,2-a]quinoline derivatives were used to synthesize novel bridgehead cyanine dyes such as azamethine, monomethine, and trimethine cyanines. The electronic absorption spectra of these cationic dyes in ethanol and several organic solvents are discussed.

Proceedings – Indian Academy of Sciences, Chemical Sciences published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Synthetic Route of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abd El-Aal, Reda Mahmoud published the artcileThe synthesis of some bridgehead heterocyclic monomethine cyanine dyes, Application In Synthesis of 606-55-3, the publication is Dyes and Pigments (1998), 39(4), 267-280, database is CAplus.

α-Chloroacetic acid and phenacyl bromide were used as reagents reacting with 8-hydroxyquinoline to form bridgehead heterocycles. Reaction of these heterocycles with equi- or dimolar ratios of ethiodides of α- or -γ-picoline or quinaldine afforded a series of monomethine and bismonomethine cyanine dyes. The electronic spectra of the monomethine cyanine dyes in various solvents are discussed.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application In Synthesis of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schindler, Lisa published the artcileMacrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells, Category: iodides-buliding-blocks, the publication is Journal of Leukocyte Biology (2021), 110(5), 893-905, database is CAplus and MEDLINE.

The chemokine-like inflammatory cytokine macrophage migration inhibitory factor (MIF) is a pivotal driver of acute and chronic inflammatory conditions, cardiovascular disease, autoimmunity, and cancer. MIF modulates the early inflammatory response through various mechanisms, including regulation of neutrophil recruitment and fate, but the mechanisms and the role of the more recently described MIF homolog MIF-2 (D-dopachrome tautomerase; D-DT) are incompletely understood. Here, we show that both MIF and MIF-2/D-DT inhibit neutrophil apoptosis. This is not a direct effect, but involves the activation of mononuclear cells, which secrete CXCL8 and other prosurvival mediators to promote neutrophil survival. Individually, CXCL8 and MIF (or MIF-2) did not significantly inhibit neutrophil apoptosis, but in combination they elicited a synergistic response, promoting neutrophil survival even in the absence of mononuclear cells. The use of receptor-specific inhibitors provided evidence for a causal role of the noncognate MIF receptor CXCR2 expressed on both monocytes and neutrophils in MIF-mediated neutrophil survival. We suggest that the ability to inhibit neutrophil apoptosis contributes to the proinflammatory role ascribed to MIF, and propose that blocking the interaction between MIF and CXCR2 could be an important anti-inflammatory strategy in the early inflammatory response.

Journal of Leukocyte Biology published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com