Microwave-Assisted Domino Heck Cyclization and Phosphorylation: Synthesis of Phosphorus Containing Heterocycles was written by Ramesh, Karu;Satyanarayana, Gedu. And the article was included in European Journal of Organic Chemistry in 2019.Safety of 4-Bromo-2-iodophenol This article mentions the following:
A domino [Pd]-catalyzed intramol. Heck cyclization of 2-iodophenyl allyl ethers, esters and amides followed by intermol. phosphorylation with secondary phosphine oxides HP(O)Ar2, for the construction of 3-phosphinylmethyl 2,3-dihydrobenzofurans is presented. Notably, the process is accelerated by microwave heating conditions and enabled the construction of C-C and C-P bonds in short reaction times. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Safety of 4-Bromo-2-iodophenol).
4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Safety of 4-Bromo-2-iodophenol
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com