Watanabe, Daisuke published the artcileSynthesis of desmosine-d4: Improvement of isotopic purity by D-H exchange of amino groups, Computed Properties of 161370-66-7, the publication is Tetrahedron Letters (2017), 58(12), 1194-1197, database is CAplus.
Desmosine is a crosslinking pyridinium amino acid of elastin, which is a useful biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD) by LC-MS/MS anal. We previously reported a synthesis of desmosine-d4, which is useful as an internal standard for quant. LC-MS/MS anal. of desmosines, by deuterogenation of an alkyne group; however, the isotopic purity of the desmosine-d4 was only ca. 50%. The present report describes a new synthesis of desmosine-d4 that improves the isotopic purity to ca. 90% by exchanging the protons of the amino groups to deuterium using deuterogenation.
Tetrahedron Letters published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C12H15BF2O2, Computed Properties of 161370-66-7.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com