Tian, Minggang published the artcileDual-Emissive Probe for Reversible Visualization of ΔΨm Revealing Voltage Heterogeneity in a Single Mitochondrion, Synthetic Route of 638-45-9, the publication is Analytical Chemistry (Washington, DC, United States) (2021), 93(7), 3493-3501, database is CAplus and MEDLINE.
Mitochondrial membrane potential (ΔΨm) is a fundamentally important parameter in eukaryotic cells playing central roles in various vital biol. processes. Precise visualization of ΔΨm depends on the robust ratiometric fluorescent probes. In this work, a new dual-emissive fluorescent probe has been fabricated for ratiometric visualization of ΔΨm. The unique probe can form near-IR emissive aggregates (~670 nm) in mitochondria with high ΔΨm, which turned to green-emitting monomers (530 nm) with loss of ΔΨm. The reversible changes of ΔΨm can be clearly observed, and the ultralarge emission shift (~140 nm) is greatly favorable for the clear observation of voltage distribution under a super-resolution microscope. With the robust probe, the heterogenous voltage distribution in a single mitochondrion has been revealed for the first time, which can facilitate the in-depth understanding of fine structures in mitochondria. The cell damages induced by various reagents were successfully visualized using the innovative probe, demonstrating its pronounced potential for biol. research.
Analytical Chemistry (Washington, DC, United States) published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C10H9IO4, Synthetic Route of 638-45-9.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com