Jones, Brian P. published the artcileThe synthesis of an aminohexyl-containing analog of the chromanol leukotriene B4 receptor antagonist CP-195543: a scaffold for the preparation of derivatized analogs, Safety of Dimethyl 2-iodoterephthalate, the publication is Heterocycles (2000), 53(8), 1713-1724, database is CAplus.
In order to allow the preparation of labeled derivatives of the leukotriene B4 (LTB4) antagonist CP-195543 for the study and/or “visualization” of LTB4 receptors in in vitro and in vivo settings, we have synthesized an aminohexyl-containing analog as a scaffold from which the requisite compounds can be prepared The key reactions in the preparation of the analog include the DAST-mediated introduction of a difluoromethylene group in the presence of an azide and a Suzuki coupling between this highly functionalized benzoate and a chromanol-derived boronic acid. 2-(3S,4R)-(3-Benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoro-7-methanesulfonamidoheptyl)benzoic acid, prepared from the analog by methanesulfonylation and saponification, is a potent LTB4 receptor antagonist but displays a high degree of non-specific binding.
Heterocycles published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Safety of Dimethyl 2-iodoterephthalate.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com