Amino Acids published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Computed Properties of 161370-66-7.
Gleede, Tassilo published the artcileInvestigation of SN2 [11C]cyanation for base-sensitive substrates: an improved radiosynthesis of L-[5-11C]-glutamine, Computed Properties of 161370-66-7, the publication is Amino Acids (2015), 47(3), 525-533, database is CAplus and MEDLINE.
Carbon-11 (β+ emitter, t1/2 = 20.4 min) radiolabeled L-glutamine is a potentially useful mol. imaging agent that can be utilized with positron emission tomog. for both human oncol. diagnosis and plant imaging research. Based upon a previously reported [11C]cyanide end-capping labeling method, a systematic investigation of nucleophilic cyanation reactions and acidic hydrolysis reaction parameters, including base, metal ion source, phase transfer catalyst, solvent, reaction temperature and reaction time, was conducted. The result was a milder, more reliable, two-step method which provides L-[5-11C]-glutamine with a radiochem. yield of 63.8 ± 8.7% (range from 51 to 74%, n = 10) with >90% radiochem. purity and >90% enantiomeric purity. The total synthesis time was 40-50 min from the end of bombardment. In addition, an Fmoc derivatization method was developed to measure the specific activity of this radiotracer.
Amino Acids published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Computed Properties of 161370-66-7.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com