Yang, Chengbin published the artcileDiscovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity, SDS of cas: 757978-19-1, the publication is ACS Medicinal Chemistry Letters (2017), 8(8), 875-880, database is CAplus and MEDLINE.
The phosphoinositide 3-kinase (PI3K) inhibitors potently inhibit the signaling pathway of PI3K/AKT/mTOR, which provides a promising new approach for the molecularly targeted cancer therapy. In this work, a novel series of 7-azaindole scaffold derivatives was discovered by the fragment-based growing strategy. The structure-activity relationship profiles identified that the 7-azaindole scaffold derivatives exhibit potent activity against PI3K at mol. and cellular levels as well as cell proliferation in a panel of human tumor cells.
ACS Medicinal Chemistry Letters published new progress about 757978-19-1. 757978-19-1 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Bromide,Iodide,Sulfamide,Benzene, name is 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, and the molecular formula is C10H9ClN2O, SDS of cas: 757978-19-1.
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https://en.wikipedia.org/wiki/Iodide,
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