Xu, F. Z. published the artcileDesign, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety, SDS of cas: 39115-95-2, the publication is RSC Advances (2018), 8(12), 6306-6314, database is CAplus and MEDLINE.
A series of trifluoromethyl pyridine derivatives containing 1,3,4-oxadiazole moiety I (R = H, 3-Cl-4-CH3, 3-CH3, etc.) was designed, synthesized and bio-assayed for their insecticidal activity. The result of bio-assays indicated the synthesized compounds exhibited good insecticidal activity against Mythimna separata and Plutella xylostella, most of the title compounds show 100% insecticidal activity at 500 mg L-1 and >80% activity at 250 mg L-1 against the two pests. Compounds I (R = 2-CF3) and 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-(4-fluorobenzyl)-1,3,4-oxadiazole showed LC50 values of 38.5 and 30.8 mg L-1 against Mythimna separata, resp., which were close to that of avermectin (29.6 mg L-1). Compounds I (R = 3,5-Cl2, 4-C2H5, 2-Cl-5-Br, 4-I, 3,4-Cl2, 2-I, 3-N(CH3)2) and 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-(4-fluorobenzyl)-1,3,4-oxadiazole showed 100% activity at 250 mg L-1, which were better than chlorpyrifos (87%). CoMFA and CoMSIA models with good predictability were proposed, which revealed the electron-withdrawing groups with an appropriate bulk at 2- and 4-positions of benzene ring could enhance insecticidal activity.
RSC Advances published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C17H20ClN3, SDS of cas: 39115-95-2.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com