Valente, Sergio published the artcile1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells, Application of 4-Iodobenzohydrazide, the publication is Journal of Medicinal Chemistry (2014), 57(14), 6259-6265, database is CAplus and MEDLINE.
We describe 1,3,4-oxadiazole-containing hydroxamates and 2-aminoanilides as histone deacetylase inhibitors. Among them, N-hydroxy-3-(4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)phenyl) acrylamide (1), N-hydroxy-4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)benzamide (2), and N-(2-aminophenyl)-4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)benzamide (3) were the most potent and selective against HDAC1. In U937 leukemia cells, (1) was more potent than vorinostat (SAHA) in inducing apoptosis, and (3) displayed cell differentiation with a potency similar to MS-275. In several acute myeloid leukemia (AML) cell lines, as well as in U937 cells in combination with doxorubicin, (3) showed higher antiproliferative effects than SAHA.
Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C14H10N2O, Application of 4-Iodobenzohydrazide.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com