Tian, Chengze published the artcileDiscovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity, Quality Control of 638-45-9, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 128271, database is CAplus and MEDLINE.
Cinnoline is a potential pharmacophore which has rarely been reported for uses as PI3K inhibitors. In this study, a series of cinnoline derivatives were developed as PI3K inhibitors and evaluated for enzymic and cellular activities. Most compounds displayed nanomolar inhibitory activities against PI3Ks, among which 25 displayed high LLE and micromolar inhibitory potency against three human tumor cell lines (IC50 = 0.264μM, 2.04μM, 1.14μM).
Bioorganic & Medicinal Chemistry Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C18H34N4O5S, Quality Control of 638-45-9.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com