Month: December 2022

Synthesis of benzimidazoles by CuI-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde in water was written by Ke, Fang;Zhang, Peng;Lin, Chen;Lin, Xiaoyan;Xu, Jianhua;Zhou, Xiangge. And the article was included in Organic & Biomolecular Chemistry in 2018.Application of 220185-63-7 This article mentions the following:

An efficient copper-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde for the synthesis of benzimidazoles I [R¹ = H, 5-Me, 5-Cl, 5-NO₂, 5,6-di-Cl, 5-Br; R² = i-Pr, Ph, 2-pyridyl, etc.] with 1,10-phenanthroline as the ligand was developed. In this copper catalytic system, a new reaction mechanism was developed and neat water was used as the solvent. A variety of substituted benzimidazole derivatives were obtained in yields up to 95% with diverse functional group tolerance. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7Application of 220185-63-7).

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Application of 220185-63-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New Reagent for Highly Efficient Synthesis of Trifluoromethyl-Substituted Arenes and Heteroarenes was written by Zhang, Xiaomin;Wang, Jian;Wan, Zehong. And the article was included in Organic Letters in 2015.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

A new reagent trimethylsilyl chlorodifluoroacetate (TCDA) is reported for the introduction of a -CF₃ group to arenes and heteroarenes. Compared with current known reagents, TCDA shows very broad scope with respect to electron-deficient, -neutral, and -rich aryl/heteroaryl iodides as well as excellent functional group tolerance, including ester, amide, aldehyde, hydroxyl, and carboxylic acid. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Recommanded Product: 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mechanochemically Generated Calcium-Based Heavy Grignard Reagents and Their Application to Carbon-Carbon Bond-Forming Reactions was written by Gao, Pan;Jiang, Julong;Maeda, Satoshi;Kubota, Koji;Ito, Hajime. And the article was included in Angewandte Chemie, International Edition in 2022.Computed Properties of C4H8ClI This article mentions the following:

Here, a mechanochem. technique using ball milling allows the generation of calcium-based heavy Grignard reagents from aryl halides and com. available calcium metal without complicated pre-activation processes was showed. Notably, all exptl. operations can be carried out in air. Our operationally simple protocol enables the rapid development of novel cross-electrophile-coupling reactions mediated by arylcalcium nucleophiles, which are rather difficult using conventional Grignard reagents. This method will allow synthetic chemists to readily access the novel and unique reactivity of organocalcium nucleophiles. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Computed Properties of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Computed Properties of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Room temperature charge-transfer phosphorescence from organic donor-acceptor Co-crystals was written by Garain, Swadhin;Ansari, Shagufi Naz;Kongasseri, Anju Ajayan;Chandra Garain, Bidhan;Pati, Swapan K.;George, Subi J.. And the article was included in Chemical Science in 2022.COA of Formula: C10H12I2 This article mentions the following:

Engineering the electronic excited state manifolds of organic mols. can give rise to various functional outcomes, including ambient triplet harvesting, that has received prodigious attention in the recent past. Herein, we introduce a modular, non-covalent approach to bias the entire excited state landscape of an organic mol. using tunable ‘through-space charge-transfer’ interactions with appropriate donors. Although charge-transfer (CT) donor-acceptor complexes have been extensively explored as functional and supramol. motifs in the realm of soft organic materials, they could not imprint their potentiality in the field of luminescent materials, and it still remains as a challenge. Thus, in the present study, we investigate the modulation of the excited state emission characteristics of a simple pyromellitic diimide derivative on complexation with appropriate donor mols. of varying electronic characteristics to demonstrate the selective harvesting of emission from its locally excited (LE) and CT singlet and triplet states. Remarkably, co-crystallization of the pyromellitic diimide with heavy-atom substituted and electron-rich aromatic donors leads to an unprecedented ambient CT phosphorescence with impressive efficiency and notable lifetime. Further, gradual minimizing of the electron-donating strength of the donors from 1,4-diiodo-2,3,5,6-tetramethylbenzene (or 1,2-diiodo-3,4,5,6-tetramethylbenzene) to 1,2-diiodo-4,5-dimethylbenzene and 1-bromo-4-iodobenzene modulates the source of ambient phosphorescence emission from the ³CT excited state to ³LE excited state. Through comprehensive spectroscopic, theor. studies, and single-crystal analyses, we elucidate the unparalleled role of intermol. donor-acceptor interactions to toggle between the emissive excited states and stabilize the triplet excitons. We envisage that the present study will be able to provide new and innovative dimensions to the existing mol. designs employed for triplet harvesting. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1COA of Formula: C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.COA of Formula: C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Microwave-Assisted Domino Heck Cyclization and Phosphorylation: Synthesis of Phosphorus Containing Heterocycles was written by Ramesh, Karu;Satyanarayana, Gedu. And the article was included in European Journal of Organic Chemistry in 2019.Safety of 4-Bromo-2-iodophenol This article mentions the following:

A domino [Pd]-catalyzed intramol. Heck cyclization of 2-iodophenyl allyl ethers, esters and amides followed by intermol. phosphorylation with secondary phosphine oxides HP(O)Ar₂, for the construction of 3-phosphinylmethyl 2,3-dihydrobenzofurans is presented. Notably, the process is accelerated by microwave heating conditions and enabled the construction of C-C and C-P bonds in short reaction times. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Safety of 4-Bromo-2-iodophenol).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Safety of 4-Bromo-2-iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A re-investigation of ⁴J_FF and ⁵J_FF nuclear spin-spin couplings in substituted benzenes, a novel conformational tool was written by Abraham, Raymond J.;Cooper, M. Ashley. And the article was included in Physical Chemistry Chemical Physics in 2016.Recommanded Product: 64248-57-3 This article mentions the following:

A theor. anal. of the ⁴J_FF and ⁵J_FF couplings in fluorobenzenes separates the σ and π components of the substituent coefficients The π bond mechanism is dominant but the σ bond mechanism must be included to give accurate values of the couplings. For monosubstituted difluorobenzenes the ⁴J_FF and ⁵J_FF couplings can be predicted from the calculated π densities by linear equations. The use of additive substituent effects allows the prediction of the meta⁴J_FF couplings for multisubstituted compounds The π dependence of the ⁴J_FF coupling in 2,6-difluorobenzenes provides a novel and simple method of determining the torsional angle of the C₁ substituent and the benzene ring for non-sym. functional groups (acetyl, carboxymethyl, dimethylamino, amide, nitro etc.). This could be used to determine the geometries of such mols. in biol. systems. The π dependence of the ⁴J_FF coupling is also of importance in the charged species of 2,6-difluoroanilinium (⁴J_FF 2.1 Hz) and 2,6-difluoro-N,N,N-trimethylanilinium (⁴J_FF 0.0 Hz) due to the very different π electron densities. In the experiment, the researchers used many compounds, for example, 1,2-Difluoro-3-iodobenzene (cas: 64248-57-3Recommanded Product: 64248-57-3).

1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Recommanded Product: 64248-57-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of functionalized 3-isochromanones via metal-free intramolecular alkoxylation-initiated cascade cyclization was written by Zhang, Ying-Qi;Zhu, Xin-Qi;Xu, Yin;Bu, Hao-Zhen;Wang, Jia-Le;Zhai, Tong-Yi;Zhou, Jin-Mei;Ye, Long-Wu. And the article was included in Green Chemistry in 2019.Product Details of 877264-43-2 This article mentions the following:

A metal-free intramol. alkoxylation-initiated cascade cyclization of allyl ether-tethered ynamides was developed. Various highly functionalized 3-isochromanones were obtained in generally good to excellent yields under mild reaction conditions. Moreover, this asym. cyclization was also realized via a stereocontrolled [3,3] rearrangement by employing a traceless chiral directing group. In addition, an unexpected [1,3] O-to-C rearrangement was observed in the case of the ynamide substrate bearing a phenyl-substituted alkene, which was distinctively different from the related gold catalysis. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Product Details of 877264-43-2).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Product Details of 877264-43-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed triple coupling of 2-iodoanisoles with aryl iodides to access 6H-dibenzopyrans was written by Chen, Li-Ping;Cheng, Shu-Lin;Fan, Xin-Yue;Zhu, Ji-Fa;Wang, Bi-Qin;Feng, Chun;Xiang, Shi-Kai. And the article was included in Organic Chemistry Frontiers in 2022.Application of 5460-32-2 This article mentions the following:

A palladium-catalyzed triple coupling of 2-iodoanisoles with aryl iodides was developed. 3-Methyl-2-pyridone was used as a ligand to accelerate the cross-coupling and suppress the homo-coupling of 2-iodoanisoles. A variety of 6H-dibenzopyran derivatives such as I [R = H, F, Cl, etc., R¹ = 4-Me, 4-F, 4-MeO, etc.; R² = 8-Me, 8-Cl, 8-Ph, etc.] was prepared by this method. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Application of 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Application of 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Assembly of a series of zinc coordination polymers based on 1,4-bis[2-(4-pyridyl)ethenyl]-2,3,5,6-tetramethylbenzene and 1,3-benzenedicarboxylate derivatives was written by Ge, Yu;Li, Ni-Ya;Ji, Xue-Ying;Wang, Jun-Feng;Liu, Dong;Tang, Xiao-Yan. And the article was included in CrystEngComm in 2014.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

Five new coordination polymers, namely, [Zn(1,3-BDC)(1,4-bpetmb)]_n (1), {[Zn₂(5-Cl-1,3-BDC)₂(1,4-bpetmb)₂]·MeCN}_n (2), [Zn(5-NO₂-1,3-BDC)(1,4-bpetmb)_0.5]_n (3), {[Zn(5-NH₂-1,3-BDC)(1,4-bpetmb)_0.5]·2H₂O}_n (4) and [Zn₂(μ-OH)(1,3,5-BTC)(1,4-bpetmb)]_n (5) have been synthesized under solvothermal conditions, based on the bis-pyridyl linker 1,4-bis[2-(4-pyridyl)ethenyl]-2,3,5,6-tetramethylbenzene (1,4-bpetmb) along with 1,3-benzenedicarboxylate (1,3-BDC) or its derivatives such as 5-chloro-1,3-benzenedicarboxylate (5-Cl-1,3-BDC), 5-nitro-1,3-benzenedicarboxylate (5-NO₂-1,3-BDC), 5-amino-1,3-benzenedicarboxylate (5-NH₂-1,3-BDC) and 1,3,5-benzenetricarboxylate (1,3,5-BTC). Compounds 1–5 have been characterized by elemental anal., IR spectroscopy, powder x-ray diffraction (PXRD) and unambiguously by single crystal X-ray diffraction anal. 1 And 2 feature the 2D (4,4) net. 3 Comprises an interlocked 3D framework, and the 3D framework is derived from the inclined interpenetration of the 2D (4,4) net. 4 Exhibits a thick 2D (3,4)-connected network with a Schlafli symbol of (6³)(6⁵·8). 5 Displays a 3D two-fold interpenetrating (3,5)-connected framework with the Schlafli symbol of (6³)(6⁷·8³). Thermal stability and solid-state photoluminescence properties of 1–5 were also investigated. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com