Month: November 2022

Antonious, Maged S. published the artcileSolvent polarity indicators: mass spectral properties of some styryl pyridinium and quinolinium salts, Product Details of C12H14IN, the publication is Annali di Chimica (Rome, Italy) (1993), 83(9-10), 457-60, database is CAplus.

I (R = H, RR = CH:CHCH:CH; R¹ = H, NMe₂, NO₂) were prepared by reaction of 2-methylpyridinium ethiodide or quinaldinium ethiodide with the corresponding benzaldehyde derivative The fragmentation pathways of I during mass spectrometry were studied.

Annali di Chimica (Rome, Italy) published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Metzger, Jurgen O. published the artcileRadical additions of alkyl 2-haloalkanoates and 2-haloalkanenitriles to alkenes initiated by electron transfer from copper in solvent-free systems, COA of Formula: C5H9IO2, the publication is Liebigs Annalen/Recueil (1997), 2303-2313, database is CAplus.

Alkyl 2-iodoalkanoates and 2-iodoalkanenitriles were added with Cu powder to the 1-alkenes RCH₂CH:CH₂ [R = (CH₂)₇CO₂Me, (CH₂)₄Me, OH, C(CO₂Et)₂CH₂CH:CH₂] and to the alkenes (Z)-R(CH₂)₂CH:CH(CH₂)₂R¹ [R = (CH₂)₅Me, R¹ = (CH₂)₅CO₂Me; R = (CH₂)₅Me, R¹ = (CH₂)₉CO₂Me; R = (CH₂)₈Me, R¹ = (CH₂)₂CO₂Me; RR¹ = bond] to give γ-lactones and 4-iodoalkanenitriles, resp., in very good yields. No solvent was used. The reaction is a free-radical addition initiated by electron transfer from Cu to the activated iodoalkane. Yields were lower using the resp. bromo compounds In-situ formation of the iodo compounds by addition of stoichiometric amounts of NaI to the reaction mixture gave improved yields. In the case of bromomalonates, the addition of NaI proved to be unnecessary. The diastereoselectivity of the addition reaction by relative 1,3-asym. induction was rationalized by consideration of the steric interactions of the substituents in the transition state which is formed in the process of I transfer to the chiral adduct radical.

Liebigs Annalen/Recueil published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, COA of Formula: C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Metzger, Juergen O. published the artcileRadical additions of activated haloalkanes to alkenes initiated by electron transfer from copper in solvent-free systems, Product Details of C5H9IO2, the publication is Angewandte Chemie, International Edition in English (1995), 34(8), 902-4, database is CAplus.

The solventless first radical addition of alkyl α-iodocarboxylates or α-iodoalkanenitriles to alkenes over copper metal involves an electron transfer initiated mechanism. The synthetic utility of this method is discussed.

Angewandte Chemie, International Edition in English published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Product Details of C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Malet-Sanz, Laia published the artcileA safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor, Recommanded Product: 5-Bromo-2-iodobenzotrifluoride, the publication is Tetrahedron Letters (2009), 50(52), 7263-7267, database is CAplus.

A method for the safe and reliable iododeamination of aromatic and heteroaromatic amines under copper-free conditions is described and its scope is evaluated. In all the experiments 1.5 equiv of t-BuONO was used and the amount of iodine was kept at 1 mol equivalent E.g., under these conditions, 4-NCC₆H₄NH₂ gave 91% 4-NCC₆H₄I.

Tetrahedron Letters published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C7H3BrF3I, Recommanded Product: 5-Bromo-2-iodobenzotrifluoride.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Ting-Ting published the artcileElectrochemical Alkoxyhalogenation of Alkenes with Organohalides as the Halide Sources via Dehalogenation, Quality Control of 31253-08-4, the publication is Organic Letters (2020), 22(18), 7250-7254, database is CAplus and MEDLINE.

A general, ideal atom use electrochem. technol. to enable alkene alkoxyhalogenation and organohalide dehalogenation in one pot is presented. This technol. is highlighted by convergent strategy integrating several reactions, such as alkene alkoxyhalogenation, organohalide dehalogenation, and dehalogenation deuteration. Exptl. data suggest that alkenes have the lowest oxidation potential, which lead to anodic conversion of the C=C bond to the radical cation intermediates, and cathodic transformations of organohalides, including alkyl and aryl halides, as the nucleophilic halogen sources.

Organic Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C7H7BClFO3, Quality Control of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lugovskii, A. P. published the artcileSynthesis and photodynamic effect of meso-substituted tricarbocyanine dyes with ortho-phenylene bridge in chromophore chain, SDS of cas: 606-55-3, the publication is Vestnik BGU, Seriya 2: Khimiya, Biologiya, Geografiya (2011), 14-18, database is CAplus.

Meso-chlorine and meso-fluorine substituted tricarbocyanine dyes with ortho-phenylene bridge in the chromophore are synthesized. The replacement of meso-chlorine to meso-fluorine in polyene system of synthon of the received dyes is investigated. A number of the synthesized substances have shown high photodynamic activity in vitro.

Vestnik BGU, Seriya 2: Khimiya, Biologiya, Geografiya published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, SDS of cas: 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Chengbin published the artcileDevelopment of anti-breast cancer PI3K inhibitors based on 7-azaindole derivatives through scaffold hopping: Design, synthesis and in vitro biological evaluation, Application of 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, the publication is Bioorganic Chemistry (2021), 105405, database is CAplus and MEDLINE.

Breast cancer is the cancer with the highest incidence all over the world. Phosphatidylinositol 3-kinase is an important regulator of intracellular signaling pathways, which is frequently mutated and overexpressed in majority of human breast cancers, and the inhibition of PI3K has been considered as a promising approach for the treatment of the cancer. Here, we report our design and synthesis of new 7-azaindole derivatives as PI3K inhibitors through the scaffold hopping strategy. By varying the groups at the 3-position of 7-azaindole, we identified a series of potent PI3K inhibitors, whose antiproliferative activities against two human breast cancer MCF-7 and MDA-MB-231 cell lines were evaluated. Representative derivatives FD2054 and FD2078 showed better activity than BKM120 in antiproliferation, reduced the levels of phospho-AKT and induced cell apoptosis. All these results suggested that FD2054 and FD2078 are potent PI3K inhibitors that could be considered as potential candidates for the development of anticancer agents.

Bioorganic Chemistry published new progress about 757978-19-1. 757978-19-1 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Bromide,Iodide,Sulfamide,Benzene, name is 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, and the molecular formula is C7H7IN2O, Application of 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Fei published the artcileTransition-metal- and phosphorus-free electrophilic trifluoromethylthiolation of indoles with sodium trifluoromethanesulfinate in ionic liquids, Recommanded Product: 1-Iodohexane, the publication is Tetrahedron Letters (2021), 153015, database is CAplus.

An acid-promoted protocol has been developed to achieve the transition-metal- and phosphorus-free electrophilic trifluoromethylthiolation of indoles I (R = H, 4-Me, 5-benzyloxy, 6-F, etc.; R¹ = H, Me, Et; R² = H, Ph) using sodium trifluoromethanesulfinate in an imidazolium-based ionic liquid ([Hmim]Br) to obtain subtd. ((trifluoromethyl)thio)-1H-indole derivatives II. The [Hmim]Br not only acts as a recyclable solvent, but also as the reductant in this transformation. The advantages of this chem. include simple operation, use of a recyclable solvent, avoidance of transition-metal and phosphorus, and gram-scale synthesis.

Tetrahedron Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C9H9F5Si, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Moreton, Jessica C. published the artcileAn X-ray Photoelectron Spectroscopy Study of Postsynthetic Exchange in UiO-66, Recommanded Product: Dimethyl 2-iodoterephthalate, the publication is Langmuir (2022), 38(4), 1589-1599, database is CAplus and MEDLINE.

Postsynthetic exchange (PSE) is a method that is widely used to change the composition of metal-organic frameworks (MOFs) by replacing connecting linkers or metal nodes after the framework was synthesized. However, few techniques can probe the nature and distribution of exchanged species following PSE. Herein, XPS can be used to compare the relative concentrations of exchanged ligands at the surface and interior regions of MOF particles. Specifically, PSE of iodobenzene dicarboxylate ligands results in a gradient distribution from surface to bulk in UiO-66 nanoparticles that depends on PSE time. XPS also reveals differences between the surface chem. of the PSE product and that of the direct synthesis product.

Langmuir published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Recommanded Product: Dimethyl 2-iodoterephthalate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Yan published the artcileEnantioselective Rhodium-Catalyzed Dearomative Arylation or Alkenylation of Quinolinium Salts, Application of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Angewandte Chemie, International Edition (2016), 55(11), 3776-3780, database is CAplus and MEDLINE.

A highly enantioselective rhodium(I)-catalyzed dearomative arylation or alkenylation of easily available N-alkylquinolinium salts is reported, thus providing an effective and practical approach to the synthesis of dihydroquinolines in up to 99% ee. This reaction tolerates a wide range of functional groups with respect to both the organic boronic acids and the quinoline starting materials. Moreover, the synthetic utility of this protocol is demonstrated in the formal asym. synthesis of bioactive tetrahydroquinoline and the total syntheses of (-)-angustureine and (+)-cuspareine.

Angewandte Chemie, International Edition published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C15H21BO3, Application of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com