Month: November 2022

Gupta, Jeetendra Kumar published the artcileAntimicrobial screening of some newly synthesized triazoles, Category: iodides-buliding-blocks, the publication is Journal of Pure & Applied Microbiology (2017), 11(2), 1067-1077, database is CAplus.

4-Iodobenzoic acid was taken as initial reactant material which was converted into Me ester then to hydrazide and finally into triazole via dithiocarbazate salt. This triazole was treated with chloroacetyl chloride and further with secondary amines which yielded amine linked triazoles I [R = pyrrolidin-1-yl, 2-methyl-piperidin-1-yl, 4-benzyl-1-piperazinyl, etc.]. The synthesized compounds were screened for their antibacterial and antifungal activities. The study was carried out against four bacteria and three fungi by disk diffusion method using ciprofloxacin and fluconazole as reference drug for antibacterial and antifungal activities resp. Among the synthesized compounds, compounds I [R = 4-methyl-1-piperazinyl, 4-benzyl-1-piperazinyl] showed highest antibacterial and antifungal activities.

Journal of Pure & Applied Microbiology published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rodriguez-Muniz, Gemma M. published the artcileModulation by Phosphonium Ions of the Activity of Mitotropic Agents Based on the Chemiluminescence of Luminols, HPLC of Formula: 638-45-9, the publication is Molecules (2022), 27(4), 1245, database is CAplus and MEDLINE.

Mitochondria-targeting drugs and diagnostics are used in the monitoring and treatment of mitochondrial pathologies. In this respect, a great number of functional compounds have been made mitotropic by covalently attaching the active moiety onto a triphenylphosphonium (TPP) cation. In this regard, luminol (probably the most widely known chemiluminescent mol.) has been employed for a number of biol. applications, including ROS detection. Hence, the photophys. interaction between the light-emitting species 3AP * and TPP cations needs to be evaluated, as it can add valuable information on the design of novel emission-based mitotropic systems. Author’s herein investigate the quenching effect of ethyltriphenylphosphonium cation onto substituted 3-aminophthalates. These were prepared in situ upon hydrolysis of the corresponding anhydrides, which were synthesized from 3-aminophthalimides. Steady-state fluorescence and time-resolved experiments were employed for the evaluation of a possible electron transfer quenching by phosphonium ions. A minor contribution of static quenching that was also detected is attributed to complex formation in the ground state. Accordingly, the chemiluminescence of luminol was indeed strongly reduced in the presence of phosphonium ions. Author’s results have to be taken into account during the design of new chemiluminescent mitotropic drugs or diagnostic agents of the luminol family.

Molecules published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, HPLC of Formula: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iwasaki, Masayuki published the artcileRegioselective Synthesis of γ-Lactones by Iron-Catalyzed Radical Annulation of Alkenes with α-Halocarboxylic Acids and Their Derivatives, Recommanded Product: Ethyl 2-Iodopropionate, the publication is Organic Letters (2018), 20(13), 3848-3852, database is CAplus and MEDLINE.

An abundant and low toxicity iron catalyst has enabled regioselective annulation of alkenes with α-halocarboxylic acids and their derivatives The reaction proceeds smoothly without any addnl. ligands, bases, and additives to afford a variety of γ-lactones in good yields. A proposed reaction pathway through radical annulation is supported by some mechanistic studies, involving radical clock and isotope labeling experiments The present method was applied to the practical iron-powder-promoted synthesis of γ-lactones.

Organic Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Recommanded Product: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Wei published the artcileEnhancing Transition Dipole Moments of Heterocyclic Semiconductors via Rational Nitrogen-Substitution for Sensitive Near Infrared Detection, Formula: C6H13I, the publication is Advanced Materials (Weinheim, Germany) (2022), 34(28), 2201600, database is CAplus and MEDLINE.

Designing ultrastrong near-IR (NIR) absorbing organic semiconductors is a critical prerequisite for sensitive NIR thin film organic photodetectors (OPDs), especially in the region of beyond 900 nm, where the absorption coefficient of com. single crystalline silicon (c-Si) is below 10³ cm^-1. Herein, a pyrrolo[3,2-b]thieno[2,3-d]pyrrole heterocyclic core (named as BPPT) with strong electron-donating property and stretched geometry is developed. Relative to their analog Y6, BPPT-contained mols., BPPT-4F and BPPT-4Cl, show substantially upshifted and more delocalized highest occupied MOs, and larger transition dipole moments, leading to bathochromic and hyperchromic absorption spectra extending beyond 1000 nm with very large absorption coefficients (up to 3.7-4.3 x 10⁵ cm^-1) as thin films. These values are much higher than those (10⁴ to 1 x 10⁵ cm^-1) of typical organic semiconductors, and 1-2 orders higher than those of com. inorganic materials, such as c-Si, Ge, and InGaAs. The OPDs based on BPPT-4F or BPPT-4Cl blending polymer PBDB-T show high detectivity of above 10¹² Jones in a wide wavelength range of 310-1010 nm with excellent peak values of 1.3-2.2 x 10¹³ Jones, resp., which are comparable with and even better than those com. inorganic photodetectors.

Advanced Materials (Weinheim, Germany) published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C18H14BrNO5S2, Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Feng, Huan published the artcileResponsive Fluorescence Probe for Selective and Sensitive Detection of Hypochlorous Acid in Live Cells and Animals, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Chemistry – An Asian Journal (2018), 13(18), 2611-2618, database is CAplus and MEDLINE.

The development of effective bioanal. methods for rapid, sensitive and specific detection of HOCl in vitro and in vivo plays a key role for better understanding the roles of this mol. in normal and diseased conditions, but remains challenging due to the highly reactive nature of HOCl and the complicated biol. conditions. A new fluorescence probe, PQI(I), was developed for monitoring of the HOCl level in biol. samples. PQI was easily synthesized by a one-step condensation reaction. Upon addition of HOCl, significant changes in the absorption spectra and the color of the solution were noticed, facilitating the “naked eye” detection of HOCl in PBS buffer. The fluorescence of PQI is significantly increased within a few seconds, leading to “OFF-ON” fluorescence response towards HOCl. The sensing mechanism, oxidation of thioether by HOCl, was confirmed by HRMS titration anal. PQI features a large Stokes shift, high sensitivity and selectivity, and rapid fluorescence response towards HOCl. Quant. detection of HOCl in single live cells was demonstrated through fluorescence imaging and flow cytometry anal. PQI was then successfully used in visualization of HOCl in live zebrafish and nude mice.

Chemistry – An Asian Journal published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kolmel, Dominik K. published the artcileOn-DNA Decarboxylative Arylation: Merging Photoredox with Nickel Catalysis in Water, HPLC of Formula: 145343-76-6, the publication is ACS Combinatorial Science (2019), 21(8), 588-597, database is CAplus and MEDLINE.

A new catalytic manifold that merges photoredox with nickel catalysis in aqueous solution is presented. Specifically, the combination of a highly active, yet air-stable, nickel precatalyst with a new electron-deficient pyridyl carboxamidine ligand was key to the development of a water-compatible nickel catalysis platform, which is a crucial requirement for the preparation of DNA-encoded libraries (DELs). Together with an iridium-based photocatalyst and a powerful light source, this dual catalysis approach enabled the efficient decarboxylative arylation of α-amino acids with DNA-tagged aryl halides. This C(sp²)-C(sp³) coupling tolerates a wide variety of functional groups on both the amino acid and the aryl halide substrates. Due to the mild and DNA-compatible reaction conditions, the presented transformation holds great potential for the construction of DELs. This was further evidenced by showing that well plate-compatible LED arrays can serve as competent light sources to facilitate parallel synthesis. Lastly, we demonstrate that this procedure can serve as a blueprint toward the adaptation of other established nickel metallaphotoredox transformations to the idiosyncratic requirements of a DEL.

ACS Combinatorial Science published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, HPLC of Formula: 145343-76-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hammond, David M. published the artcileDNA photography: an ultrasensitive DNA-detection method based on photographic techniques, Product Details of C12H14IN, the publication is Angewandte Chemie, International Edition (2007), 46(22), 4184-4187, database is CAplus and MEDLINE.

All there in black and white: DNA labeled with spectral sensitizers applied to com. available photopaper allows the detection of oligonucleotides with extreme sensitivity. The detection of the DNA with the help of black and white photog. is shown in the picture (ODN = oligodeoxyribonucleotide).

Angewandte Chemie, International Edition published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Radwan, Ahmed S. published the artcileSynthesis, characterization, and self-assembly of fluorescent fluorine-containing liquid crystals, COA of Formula: C6H13I, the publication is Luminescence (2021), 36(7), 1751-1760, database is CAplus and MEDLINE.

In the current work, the synthesis, self-assembly, and mesogenic properties of new perfluorinated para-terphenyls bearing various para-substituted alkoxy and thioalkoxy chains was described. The terphenyl core was prepared using Cu(I) (or Cu(I)/phenanthroline)-catalyzed decarboxylative carbon-carbon (or carbon-oxygen [sulfur]) cross-coupling from the analogous aromatic iodide and fluorobenzoate potassium salt. The mol. structures of the prepared perfluorinated terphenyls were demonstrated with ¹H, ¹³C, and ¹⁹F NMR, as well as FT-IR and X-ray crystallog. The liquid crystalline properties and mesogenic phases were characterized with differential scanning calorimetry and high-resolution polarized optical microscope. Both UV-visible absorbance and emission spectra demonstrated solvatochromism. Supramol. self-assembly of the generated perfluorinated para-terphenyls was monitored by van der Waals and π-π stacking interaction forces. The creation of nanofibrous architectures was monitored by SEM.

Luminescence published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, COA of Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Das, Sanju published the artcileSynthesis of Polysubstituted Quinolines from α-2-Aminoaryl Alcohols Via Nickel-Catalyzed Dehydrogenative Coupling, Quality Control of 53279-83-7, the publication is Journal of Organic Chemistry (2018), 83(4), 2309-2316, database is CAplus and MEDLINE.

This study reports a nickel-catalyzed sustainable synthesis of polysubstituted quinolines, e.g. I, from α-2-aminoaryl alcs. by a sequential dehydrogenation and condensation process that offers the advantages of a low catalyst loading and wide substrate scope. In contrast to earlier reported methods, this strategy allows the use of both primary as well as secondary α-2-aminoaryl alcs. in combination with either ketones or secondary alcs. for desired product formation. Using this methodol., 30 substituted quinoline derivatives were synthesized with up to 93% isolated yields.

Journal of Organic Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Quality Control of 53279-83-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com