Month: November 2022

Gillespie, James E. published the artcileRegioselective Radical Arene Amination for the Concise Synthesis of ortho-Phenylenediamines, HPLC of Formula: 638-45-9, the publication is Journal of the American Chemical Society (2021), 143(25), 9355-9360, database is CAplus and MEDLINE.

The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactive N-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the arene ortho position. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly to ortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsym., selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuable ortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

Journal of the American Chemical Society published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, HPLC of Formula: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fujita, Morifumi published the artcileAsymmetric Synthesis of 4,8-Dihydroxyisochroman-1-one Polyketide Metabolites Using Chiral Hypervalent Iodine(III), Safety of Dimethyl 2-iodoterephthalate, the publication is Organic Letters (2012), 14(5), 1294-1297, database is CAplus and MEDLINE.

Stereoselective oxylactonization of ortho-alkenylbenzoate with chiral hypervalent iodine is applied to the asym. synthesis of 4-oxyisochroman-1-one polyketide metabolites including 4-hydroxymellein (I), a derivative of fusarentin II, monocerin (3), and an epimer III of monocerin.

Organic Letters published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Safety of Dimethyl 2-iodoterephthalate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bolton, Roger published the artcileNucleophilic displacement in polyhaloaromatic compounds. Part 11. Kinetics of protiodeiodination of iodoarenes in dimethyl sulfoxide-methanol, COA of Formula: C7H3BrF3I, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) (1982), 1593-8, database is CAplus.

The kinetics were determined of the MeO^–-induced protiodeiodination of 15 polychloroiodobenzenes and 6 of their Br- or CF₃-substituted analogs in 9:1 (volume) DMSO-MeOH at 323.2 K. The true reagent is the DMSO anion. The reaction rates in some cases approached the diffusion-controlled process. Cl and CF₃ substituents promote the reaction in the order ortho > meta > para and ortho > para > meta, resp. Protiodeiodinaton is promoted by o-NO₂ groups, but the p-NO₂ group encourages methoxydeiodination. Unlike polychloroiodobenzenes, polychlorobenzenes underwent methoxydechlorination. A mechanism involving nucleophilic attack by a carbanion was proposed.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C7H3BrF3I, COA of Formula: C7H3BrF3I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Larsen, A. A. published the artcileIodinated 3,5-diaminobenzoic acid derivatives, Recommanded Product: Pyridine Iodochloride complex, the publication is Journal of the American Chemical Society (1956), 3210-16, database is CAplus.

ICl (55 cc.) added to 120 g. KCl in 350 cc. H₂O and adjusted to 500 cc. gave a 2N KICl₂ solution (I). KIO₃ (71 g.), 40 g. KCl, and 5 cc. concentrated HCl in 80 cc. H₂O treated with stirring with 111 g. KI in 100 cc. H₂O and simultaneously with 170 cc. concentrated HCl, and the mixture adjusted to 500 cc. gave a 2N I. I (250 cc.) added with stirring to 45 cc. pyridine in 1 l. H₂O, the mixture adjusted to pH 5 with pyridine, and the crude precipitate air-dried (117 g.) and recrystallized from 700 cc. C₆H₆ gave 87 g. pyridine-ICl (II), light yellow solid, m. 135-6°. 3,5-(O₂N)₂C₆H₃CO₂H (212 g.) in 1.4 l. H₂O and 210 cc. concentrated NH₄OH heated with stirring to 70°, the mixture treated with a stream of H at such a rate as to keep the temperature at 75-80°, diluted with 800 cc. H₂O and 300 cc. concentrated HCl, cooled, and filtered, the filtrate adjusted to pH 3 with solid Na₂CO₃, and the orange precipitate recrystallized from 3.5 l. H₂O gave 160 g. 3,5-H₂N(O₂N)C₆H₃CO₂H (III), m. 211-13°. Na salt (78 g.) of III in 750 cc. H₂O treated at 40° with stirring with 43 cc. Ac₂O gave 80 g. N-Ac derivative of III, m. 291-5° (all m.ps. are corrected). Similarly were prepared: N-PrCO derivative, m. 243-5°, 76% yield; N-EtCO derivative (IV), m. 242-3°, 75%. III (91 g.) in 1.25 l. PhMe dried azeotropically, treated with 65 cc. iso-BuCOCl, refluxed 1.5 hrs., cooled, and filtered yielded 110 g. N-iso-Bu CO derivative of III, m. 223-4° (from EtOH). In the same manner were prepared the following N-acyl derivatives of III (acyl group, m.p. corrected, and % yield given): BuCO (V), 206-8°, 84; AmCO, 284-6°, 50; iso-AmCO, 206-7°, 82; C₆H₁₃CO, 170-1°, 62. III (100 g.) and 110 g. 70% HOCH₂CO₂H heated to 150°, the clear melt poured onto 3 l. crushed ice, and the precipitate reprecipitated from dilute aqueous NaOH with dilute HCl yielded 63 g. N-HOCH₂CO derivative of III, m. 231-3°. IV (98 g.) in 750 cc. H₂O dissolved at room temperature with NH₄OH, the solution hydrogenated 2 hrs. at room temperature and 500 lb. over Raney Ni and filtered, and the filtrate acidified with AcOH gave 63 g. 3,5-EtCONH(H₂N)C₆H₃CO₂H, m. 206-8°. Similarly were prepared the following 3-acylamino-5-aminobenzoic acids (VI) (acylamino group, m.p. corrected, and % yield given): PrCO, 237-8°, 75; HOCH₂CO, 204-7°, 85°. V (112 g.) in 750 cc. H₂O and 77 cc. N₂H₄.H₂O treated with 12 g. Raney Ni in 6 portions, and the mixture heated on the steam bath until foaming stopped and worked up yielded 86 g. 3,5-H₂N(BuCONH)C₆H₃CO₂H, m. 230-1° (from EtOH). Similarly were prepared the following VI (acyl group, m.p. corrected, and % yield given): Ac (VII), 222-4°, 97; iso-BuCO, 242-4°, 67; AmCO, 203-4°, 80; iso-AmCO, 224-5°, 61; C₆H₁₃CO, 183-5°, 65. VII (38.8 g.) in 1 l. H₂O and 16 cc. concentrated HCl treated dropwise during 20 min. with 210 cc. I, the mixture stirred 3 hrs., the gray solid (86 g.) filtered off, washed with H₂O, dissolved in 1 l. H₂O with NH₄OH, treated with 5 g. NaHSO₃, and acidified with 6N HCl, and the precipitate dissolved in dilute NH₄OH, charcoaled, and reprecipitated yielded 57 g. 3,5,2,6-AcNH(H₂N)I₂C₆HCO₂H (VIII), m. 215-17° (decomposition); LD₅₀ intravenous in mice 9.5 ± 0.5 g./kg. (these values are given throughout the further abstract in parentheses). In the same manner were prepared the following 3-acylamino analogs of VIII (acyl group, m.p. corrected, and % yield given): EtCO, 210-12°, 41 (10.0); PrCO (IX), 204-5°, 40 (6.94), HOCH₂CO (X), 225-7°, 40 (7.35). VIII (100 g.), 900 cc. Ac₂O, and 2 cc. concentrated H₂SO₄ heated 3 hrs. on the steam bath, the solution poured onto 3 kg. ice, allowed to stand some time, and filtered, and the residue air-dried (102 g.) and reprecipitated with acid from dilute aqueous NaOH gave 85 g. 3,5,2,6-(AcNH)₂I₂C₆HCO₂H (XI), which recrystallized from 1.5 l. EtOH and reprecipitated from the NH₄ salt gave pure XI, white solid, m. 266-8° (decomposition) (9.80 ± 0.8). Similarly were prepared the following compounds (same data given): 3,5,2,6-EtCONH(AcNH)I₂C₆HCO₂H (XII), 241-2° (from HCONMe₂), 33 (12.66); 3-AcOCH₂CONH analog of XII, 238-9° (from AcOH), 50 (8.5). VIII (33 g.), 145 cc. (PrCO)₂O, and 10 drops concentrated H₂SO₄ heated 2.5 hrs. on the steam bath, cooled, and filtered, and the residue washed with pentane and purified in the usual manner gave 16 g. 3-PrCONH analog (XIII) of XII, m. 220-1° (decomposition) (from Me₂CO) (13.00). 3,5,2,6-AcNH(AcOCH₂CONH)I₂C₆HCO₂H (23 g.) in H₂O treated gradually with 84 cc. N aqueous NaOH, filtered, and acidified gave 13 g. 3,5,2,6-HOCH₂CONH(AcNH)I₂C₆HCO₂H, white solid, m. 223-5° (decomposition) (from EtOH) (>3.6). VII (97 g.) in 2.5 l. H₂O treated with stirring during 0.5 hr. with 550 cc. I, the mixture stirred 3 hrs. at room temperature, neutralized with 155 cc. 35% aqueous NaOH, treated during 0.5 hr. with an addnl. 250 cc. I, and filtered, the residue washed with H₂O, air-dried, heated to 90° with 400 cc. saturated aqueous NH₄Cl, made ammoniacal, filtered, and cooled, the precipitated NH₄ salt dried, dissolved in 3 l. hot H₂O, and charcoaled, and the product precipitated with concentrated HCl gave 220 g. 4-iodo derivative (XIV) of VIII, white solid, m. 258-9° (decomposition) (from EtOH) (7.20 ± 0.66). Similarly were prepared the 4-iodo derivatives (m.p. and % yield given) of the following compounds: BuCONH analog of IX, 236-7° (from aqueous EtOH), 50 (5.66); X, 263-4° (from aqueous EtOH), 71 (4.32). XIV (28.6 g.) and 70 cc. iso-PrCOCl heated 4 hrs. on the steam bath, cooled, and filtered, and the residue purified in the usual manner gave 27 g. 3,5,2,4,6-AcNH(iso-PrCONH)I₃C₆CO₂H (XV), m. above 300° (from dilute EtOH) (6.87). Similarly were prepared the following 5-acylamino analogs of XV (acyl group, m.p. corrected, and % yield given): BuCO, 290-3°, 47 (6.20 ± 0.40); iso-BuCO, above 290°, 40 (3.12); AmCO, 276-8°, 60 (3.20 ± 0.16); iso-AmCO, 291-2°, 45 (2.38); C₆H₁₃CO, 294-5°, 79 (1.32 ± 0.84); C₇H₁₅CO, 278-9°, 60 (0.48 ± 0.03) (all recrystallized from aqueous EtOH). 3,5-(O₂N)₂C₆H₃CO₂H (212 g.) in 1.4 l. H₂O and 168 cc. concentrated HCl hydrogenated 0.5 hr. over 30 g. 10% Pd-C at 1500 lb. initial pressure and filtered, the filtrate diluted to 12 l. with H₂O, the solution treated with 1.6 l. I, the mixture stirred 0.5 hr. and filtered, and the residue washed and air-dried gave 475 g. crude product; 53 g. crude product and 100 cc. saturated aqueous NH₄Cl heated on the steam bath, treated with NH₄OH, and filtered, the filtrate cooled to 0°, the crystalline deposit dissolved in H₂O and treated 2 hrs. in the cold with C, and the product precipitated with AcOH yielded 42 g. 3,5,2,4,6-(H₂N)₂I₃C₆CO₂H (XVI), dull white solid, m. 154-8° (decomposition) (1.31 ± 0.13). HCO₂H (98%) (610 cc.) added as rapidly as possible below 15° with stirring to 400 cc. cold Ac₂O, the mixture treated with 53 g. XVI, warmed slowly to 50°, kept 1 hr. at 50-5°, diluted with 250 cc. H₂O, and allowed to stand overnight, the gray solid deposit washed with warm H₂O, air-dried (47 g.), suspended in 400 cc. 70% iso-PrOH and dissolved at the boiling point with 5% aqueous NaOH, the solution decolorized with C and cooled, and the resulting Na salt (34 g.) dissolved in H₂O and acidified with dilute HCl yielded 28 g. 3,5,2,4,6-(HCONH)₂I₃C₆CO₂H (XVII), m. above 300° (7.40 ± 0.44). Similarly was prepared the 3-AcNH analog of XVII, m. 261-2° (from dilute EtOH), 40% (10.8 ± 0.46). XVI (145 g.) in 750 cc. Ac₂O dissolved at 70-5°, cooled to 45-50°, treated with 10 drops concentrated H₂SO₄, heated 15 min. on the steam bath, and cooled, and the resulting crude product (137 g.) purified in the usual manner through the NH₄ salt gave 130 g. di-Ac derivative (XVIII) of XVI, white solid, m. above 300° (from 50% aqueous HCONMe₂) (13.40 ± 0.86). Similarly were prepared the following diacyl derivatives of XVI (acyl group or groups, m.p. corrected, and % yield given): EtCO, Ac, above 300°, 77 (10.0 ± 0.57); PrCO, Ac, above 300, 65 (8.70 ± 0.44); HOCH₂CO, Ac, 249-51° (from H₂O), 50 (8.50 ± 0.70); AcOCH₂CO, Ac, 284-9° (from AcOH), 55 (8.50 ± 0.74); EtCO, above 300° (from aqueous HCONMe₂), 59 (11.80 ± 0.54); PrCO, above 300° (from EtOH), 33, 7.20 ± 0.58; BuCO, above 300° (from aqueous MeOH), 33 (2.65 ± 0.18); iso-BuCO, above 300° (from aqueous MeOH), 45 (3.57); AmCO, above 300° (from aqueous MeOH), 35 (0.60 ± 0.06). 3,6-H₂N(O₂N)C₆H₃CO₂H (24 g.) and 70 g. II in 1 l. H₂O stirred 6 hrs. at room temperature, 6 hrs. on the steam bath, cooled, treated with excess NH₄OH, and filtered, the filtrate heated on the steam bath, acidified with dilute HCl, and filtered, the precipitate washed and air-dried (45.3 g.) and heated 0.5 hr. on the steam bath with 125 cc. Ac₂O and 10 drops concentrated H₂SO₄, the mixture treated cautiously with hot H₂O, and the solution kept at room temperature overnight gave 43.6 g. 3,6,2,4-AcNH(O₂N)I₂C₆HCO₂H (XIX), m. 266-7° (decomposition). XIX (9 g.) in 50 cc. H₂O and 8 cc. concentrated NH₄OH treated with 15 g. Na₂S₂O₄ at 15-20°, the solution heated 10 min. on the steam bath, cooled, adjusted with NH₄OH to pH 8-9, treated with Filer-Cel, and filtered, and the filtrate acidified with concentrated HCl, heated on the steam bath, and cooled, and the precipitate reprecipitated from the NH₄ salt gave 5.2 g. 6-NH₂ analog (XX) of XIX, m. 239-40° (decomposition). XX (30 g.) in 100 cc. H₂O and 50 cc. concentrated H₂SO₄ treated during 1.25 hrs. with stirring and cooling with 5 g. NaNO₂ in 20 cc. H₂O, the mixture stirred 1 hr., treated with H₂NSO₃H and then with 100 cc. cold 50% H₃PO₂, and stirred 10 hrs. at 0°, and the brown precipitate reprecipitated from NH₄OH gave 13.5 g. 3,2,4-AcNH(I₂)C₆H₂CO₂H (XXI), off-white, solid, m. 244-50° (decomposition), which reprecipitated from NH₄OH and recrystallized from iso-PrOH yielded 2.5 g. pure XXI, white solid, m. 264° (decomposition). VIII (44 g.) in 25 cc. concentrated HCl and 200 cc. H₂O treated during 0.5 hr. with stirring with 7 g. NaNO₂ in 20 cc. H₂O, the mixture stirred 1.5 hrs., treated with H₂NSO₃H and then with 100 cc. 50% H₃PO₂, and stirred 8 hrs. at 0°, and the resulting brown product charcoaled and reprecipitated from NH₄OH yielded 27 g. crude material which recrystallized from AcOH and reprecipitated twice from NH₄OH gave 10.5 g. 3,2,6-AcNH(I₂)C₆H₂CO₂H, m. 256° (decomposition).

Journal of the American Chemical Society published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Khansole, Sandeep V. published the artcilePyridinium iodochloride, an efficient reagent for iodination of hydroxylated aromatic ketones and aldehydes, HPLC of Formula: 6443-90-9, the publication is Journal of the Chinese Chemical Society (Taipei, Taiwan) (2008), 55(4), 871-874, database is CAplus.

Direct iodination of several reactive aromatic compounds like hydroxy substituted acetophenones and aldehydes with pyridinium iodochloride proceeded smoothly to afford the corresponding aromatic iodides in good to excellent yield. Pyridinium iodochloride was an efficient solid iodinating reagent with no hazardous effect and it can be handled safely.

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, HPLC of Formula: 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bozzi, Fabio published the artcileMIF/CD74 axis is a target for novel therapies in colon carcinomatosis, HPLC of Formula: 41270-96-6, the publication is Journal of Experimental & Clinical Cancer Research (2017), 16/1-16/15, database is CAplus and MEDLINE.

Background: Strategies aimed at obtaining a complete cytoredn. are needed to improve long-term survival for patients with colorectal cancer peritoneal carcinomatosis (CRC-pc). Methods: We established organoid models from peritoneal metastases of two naïve CRC patients. A standard paraffin inclusion was conducted to compare their 3D structure and immunohistochem. profile with that of the corresponding surgical samples. RNA expression levels of the CRC stem cell marker LGR5 was measured by in situ hybridization. The secretome of organoids was profiled by mass spectrometry. Energy homeostasis of organoids was interfered with 4-IPP and metformin. Biochem. and metabolic changes after drug treatments were investigated by western blot and mass spectrometry. Mitochondria impairment was evaluated by electron microscopy and mitotraker staining. Results: The two organoids recapitulated their corresponding clin. samples in terms of 3D structure and immmunoistochem. profile and were pos. for the cancer stem cells marker LGR5. Proteomic analyses of organoids highlighted their strong dependence on energy producing pathways, which suggest that their targeting could be an effective therapeutic approach. To test this hypothesis, we treated organoids with two drugs that target metabolism acting on AMP-activated protein kinase (AMPK), the main regulator of cellular energy homeostasis, which may act as metabolic tumor suppressor in CRC. Organoids were treated with 4-IPP, an inhibitor of MIF/CD74 signalling axis which activates AMPK function, or metformin that inhibits mitochondrial respiratory chain complex I. As a new finding we observed that treatment with 4-IPP downregulated AMPK signalling activity, reduced AKT phosphorylation and activated a JNK-mediated stress-signalling response, thus generating mitochondrial impairment and cell death. Metformin treatment enhanced AMPK activation, decreasing the activity of the anabolic factors ribosomal protein S6 and p4EBP-1 and inducing mitochondrial depolarization. Conclusions: We provide evidence that the modulation of AMPK activity may be a strategy for targeting metabolism of CRC-pc organoids.

Journal of Experimental & Clinical Cancer Research published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, HPLC of Formula: 41270-96-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Heald, Robert A. published the artcileAntitumor polycyclic acridines. 8.Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts, Product Details of C12H14IN, the publication is Journal of Medicinal Chemistry (2002), 45(3), 590-597, database is CAplus and MEDLINE.

Two short routes to novel methylated pentacyclic quinoacridinium salts have been devised. New compounds display telomerase-inhibitory potency (<1 μM) in the TRAP assay. 3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate ( RHPS4, NSC 714187) has a higher selectivity for triplex and quadruplex DNA structures than the 3,6,8,11,13-pentamethyl analog (RHPS3, NSC 714186) and a low overall growth-inhibitory activity in the NCI 60 cell panel (mean GI₅₀ 13.18 μM); in addition, the activity profile of NSC 714187 does not COMPARE with agents of the topoisomerase II class. Compound NSC 714187 is soluble in water, stable in the pH range of 5-9, efficiently transported into tumor cells, and is currently the lead structure for further elaboration in this new class of telomerase inhibitor.

Journal of Medicinal Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Haristos, Demetrius A. published the artcileKinetic study of the oxidation of benzoic acid hydrazide by mercury(II) acetate, SDS of cas: 39115-95-2, the publication is Chimika Chronika (1982), 11(3), 193-200, database is CAplus.

The oxidation kinetics of RC₆H₄CONHNH₂ (I; R = H, p-F, m-Cl, p-Cl, m-Br, p-Br, p-iodo, m-MeO, p-MeO, m-NO₂) by Hg(OAc)₂ are not dependent on inductive or resonance effects. Two possible mechanisms can explain the kinetics. In one of these, the NH₂ group N atom is involved as an electron donor in a complex with Hg²⁺. This electron transfer reaction leads to the C-N bond cleavage which gives RC₆H₄C⁺(O) and •NHNH₂. The alternative mechanism involves a 4-electron transfer in which RC₆H₄CON:NH is an intermediate.

Chimika Chronika published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Upadhyay, Prabhat Kumar published the artcileMicrowave assisted synthesis and evaluation of some substituted 1,3,4-oxadiazoles as free radical scavenger, Category: iodides-buliding-blocks, the publication is Journal of the Indian Chemical Society (2018), 95(6), 661-666, database is CAplus.

A series of 5-(4-substituted phenyl)-1,3,4-oxadiazoles I [R = Me, Br, OH, etc.] was synthesized from 4-substituted benzoic acid hydrazides and carbon disulfide. Structures of the synthesized compounds were confirmed on the basis of IR, ¹³C NMR, mass spectral methods and elemental anal. The compounds were screened for antioxidant activities using hydrogen peroxide scavenging method comparing with ascorbic acid as standard antioxidant. The results revealed that the compounds possess significant free radical scavenging activities, among them compound I [R = OH] showed highest scavenging activity.

Journal of the Indian Chemical Society published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C12H25Br, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Upadhyay, Prabhat K. published the artcileSynthesis and antimicrobial screening of some 1,3,4-oxadiazoles and their molecular properties prediction through ‘rule of five’, SDS of cas: 39115-95-2, the publication is Pakistan Journal of Pharmaceutical Sciences (2019), 32(3), 1025-1032, database is CAplus and MEDLINE.

In the current study, a series of 5-(4-substituted phenyl)-1,3,4-oxadiazole-2-thiols I (R = F, Cl, Br, I, Me, OMe, OH, OEt) were prepared from 4-substituted benzoic acid hydrazides 4-RC₆H₄C(O)NHNH₂. All these synthesized compounds I were investigated for their antibacterial activities against bacterial strains i.e. Staphylococcus aureus, Bacillus substilis, Escherichia coli and Pseudomonas aeruginosa. The strains, Aspergillus niger and Candida albicans were also examined for antifungal screening. The zone of inhibition was measured and percentage inhibition was calculated by comparing with standard drug. The min. inhibitory concentrations (MICs) of potent synthesized compounds I were determined Then, all the synthesized compounds I were computed to assess the drug-like properties through Lipinski’s rule of five. The results of in-vitro assay showed that the compounds I (R = F, Cl, I) possess significant antibacterial activity, whereas compounds I (R = F, OMe, OEt) possess significant antifungal activity. The predicted drug likeness score of all these compounds I were also meritorious among 1,3,4-oxadiazoles. The results recommended that these compounds I might be used in future to generate derivatives for emergent antimicrobial agents with improved pharmacokinetic profile.

Pakistan Journal of Pharmaceutical Sciences published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C18H28B2O4, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com