Month: November 2022

Baciocchi, Enrico published the artcileSynthesis of γ-haloesters and γ-ketoesters by homolytic addition of carbon radicals generated by α-haloesters and triethylborane to alkenes and silyl enol ethers, HPLC of Formula: 31253-08-4, the publication is Tetrahedron Letters (1994), 35(17), 2763-6, database is CAplus.

γ-Haloesters are efficiently prepared under very mild conditions by addition of electrophilic carbon radicals ·CH(R)CO₂Et (R=H, Me, CO₂Et) generated by XCH(R)CO₂Et (X=Br, iodo)/BEt₃/air in DMSO to alkenes and cycloalkenes. Thus, stirring ICH₂CO₂Et with 1-decene in DMSO in air gave 90% Me(CH₂)₇CHICH₂CH₂CO₂Et. γ-Ketoesters are obtained when silyl enol ethers are used as the substrates.

Tetrahedron Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, HPLC of Formula: 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Baciocchi, Enrico published the artcileHomolytic aromatic substitutions of pentatomic heteroaromatics with electrophilic carbon radicals generated by alkyl halides and triethylborane, Name: Ethyl 2-Iodopropionate, the publication is Tetrahedron Letters (1993), 34(31), 5015-18, database is CAplus.

An efficient homolytic aromatic substitution of pyrroles, furan, and thiophene by ^{â€?/sup>CH₂CO₂Et and â€?/sup>CH(CH₃)CO₂Et has been carried out, the radicals being generated by autoxidation of BEt₃ in the presence of XCH₂CO₂Et and XCH(CH₃)CO₂Et (X = Br, I). Thus, homolytic aromatic substitution reaction of pyrrole with BrCH₂CO₂Et in the presence of BEt₃ in C₆H₆ or DMSO and hexane gave 47% substituted pyrrole I.}

Tetrahedron Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Name: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Baciocchi, Enrico published the artcileHomolytic substitution reactions of electron-rich pentatomic heteroaromatics by electrophilic carbon-centered radicals. Synthesis of α-heteroarylacetic acids, Application of Ethyl 2-Iodopropionate, the publication is Journal of Organic Chemistry (1992), 57(25), 6817-20, database is CAplus.

Efficient and selective homolytic substitutions (55-90% yields) of pyrrole, indole, and some pyrrole derivatives have been carried out using ambiphilic and electrophilic carbon centered radicals, generated in DMSO by Fe²⁺/H₂O₂ and α-cyano-, α-carbonyl-, and α,α’-dicarbonylalkyl iodides. The reaction is highly successful with pyrroles substituted by electron-withdrawing groups, which allowed an efficient synthesis of Tolmetin. A few extensions of this reaction to furan and thiophene are described. Thus, homolytic substitution of pyrrole with ICHRR¹ (R = H, R¹ = CO₂Me, cyano; R = R¹ = CO₂Me) gave 2-substituted pyrroles I.

Journal of Organic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application of Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Khan, Madiha Sahar published the artcileSynthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors, Application of 4-Iodobenzohydrazide, the publication is Bioorganic & Medicinal Chemistry (2014), 22(3), 1195-1200, database is CAplus and MEDLINE.

A series of new N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazide derivatives were synthesized and evaluated for their α-glucosidase inhibitory activity. Some of the synthesized compounds showed significant α-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes. Structures of the synthesized compounds were determined by using FT-IR, ¹H NMR, ¹³C NMR, mass spectrometry and elemental anal. techniques.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nisa, Mehr-un published the artcileSynthesis of novel 5-(aroylhydrazinocarbonyl)escitalopram as cholinesterase inhibitors, Quality Control of 39115-95-2, the publication is European Journal of Medicinal Chemistry (2017), 396-406, database is CAplus and MEDLINE.

A novel series of 5-(aroylhydrazinocarbonyl)escitalopram were designed, synthesized and tested for their inhibitory potential against cholinesterases. N’-(3-Chlorobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide is the most potent compound of this series having IC₅₀ 1.80 ± 0.11 μM for acetylcholinesterase (AChE) inhibition. For the butyrylcholinesterase (BChE) inhibition, N’-(2-Bromobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide was the most active compound of the series with IC₅₀ 2.11 ± 0.31 μM. Structure-activity relation illustrated that mild electron donating groups enhanced enzyme inhibition while electron withdrawing groups reduced the inhibition except o-NO₂. However, size and position of the substituents affected enzyme inhibitions. In docking study of AChE, the ligands N’-(3-Chlorobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide, N’-(4-Chlorobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide and N’-(2-Bromobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide showed the scores of 5874, 5756 and 5666 and ACE of -64.92,-203.25 and -140.29 kcal/mol, resp. In case of BChE, ligands 71, 76 and 81 depicted high scores 6016, 6150 and 5994 with ACE values -170.91, -256.84 and -235.97 kcal/mol, resp.

European Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mehr-un-Nisa published the artcileSynthesis of novel triazoles and a tetrazole of escitalopram as cholinesterase inhibitors, Application In Synthesis of 39115-95-2, the publication is Bioorganic & Medicinal Chemistry (2015), 23(17), 6014-6024, database is CAplus and MEDLINE.

A novel series of escitalopram triazoles I and a tetrazole II have been synthesized and subjected to a study to establish the inhibitory potential of these compounds toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Some selectivity in inhibition has been observed The compound I (R = 4-Cl, IC₅₀, 6.71 ± 0.25 μM) and I (R = 2-Me, 70, IC₅₀, 9.52 ± 0.23 μM) escitalopram triazole derivatives depicted high AChE inhibition, while compound I (R = 2-F, IC₅₀ = 4.52 ± 0.17 μM) and I (r = 4-F, IC₅₀ = 5.31 ± 0.43 μM) have found to be excellent BChE inhibitors. It has also been observed that ortho, meta and para substituted electron donating groups increase the inhibition, while electron withdrawing groups reduce the inhibition. Docking analyses of inhibitors with AChE have depicted the binding energies for I (R = 2-Me, 4-Cl) as ΔG_bind -6.42 and -6.93 kcal/mol, resp., while ligands I (R = 2-F, 4-F) have shown the binding affinity ΔG_bind -9.04 and -8.51 kcal/mol, resp., for BChE.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Zhong’an published the artcileSupramolecular Assembly of Complementary Cyanine Salt J-Aggregates, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Journal of the American Chemical Society (2015), 137(37), 11920-11923, database is CAplus and MEDLINE.

An understanding of structure-property relationships in cyanine dyes is critical for their design and application. Anionic and cationic cyanines can be organized into complementary cyanine salts, offering potential building blocks to modulate their intra/intermol. interactions in the solid state. Here, we demonstrate how the structures of these complementary salts can be tuned to achieve highly ordered J-type supramol. aggregate structures of heptamethine dyes in crystalline solids.

Journal of the American Chemical Society published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cronk, W. Cole published the artcileIntramolecular Photoassisted Cycloadditions of Azaxylylenes and Postphotochemical Capstone Modifications via Suzuki Coupling Provide Access to Complex Polyheterocyclic Biaryls, Application In Synthesis of 53279-83-7, the publication is Journal of Organic Chemistry (2014), 79(3), 1235-1246, database is CAplus and MEDLINE.

Modular preassembly of azaxylylene photoprecursors, halogen-substituted in the aromatic ring, their intramol. [4 + 4] or [4 + 2] cycloadditions to tethered unsaturated pendants, and subsequent postphotochem. capstone modification of the primary photoproducts via Suzuki coupling provides rapid access to diverse biaryls of unprecedented topol. [e.g., I �(II + III) �(IV + V)]. This synthetic sequence allows for rapid growth of mol. complexity and is well aligned with methodol. of diversity-oriented synthesis.

Journal of Organic Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Application In Synthesis of 53279-83-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cheng, Ying published the artcileTransition metal-free 1,2-carboboration of unactivated alkenes, COA of Formula: C5H9IO2, the publication is Journal of the American Chemical Society (2018), 140(20), 6221-6225, database is CAplus and MEDLINE.

A method for transition metal-free 1,2-carboboration of unactivated alkenes with bis(catecholato)diboron as the boron source in combination with alkyl halides as the alkyl component is introduced. The three-component reaction of aryl alkenes ArX(CH₂)_nCH:CH₂ (n = 1-3; X = bond, O) with B₂cat₂ and perfluoroalkyl iodides R^FI as the photoactivated radical source proceeds via a radical pathway on a broad range of unactivated alkenes, and the 1,2-carboboration/transesterification products ArX(CH₂)_nCH(Bpin)CH₂R^F serve as valuable synthetic building blocks. D. functional theory calculations provide insights into the mechanism.

Journal of the American Chemical Society published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, COA of Formula: C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Boev, V. I. published the artcile2- And 4-methylmercurated quinolinium salts, Application of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Zhurnal Obshchei Khimii (1994), 64(7), 1128-33, database is CAplus.

Mercuration of 2- and 4-methylquinolinium salts with HgX₂ (X = OAc, O₂CCF₃) gave the corresponding mono-, di-, and trimethylmercurated quinolinium salts depending on the ratio of reactants. Some reactions of these salts are reported with CaCl₂, KI, NaOH, and Br₂ in HOAc.

Zhurnal Obshchei Khimii published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com