Rodriguez-Muniz, Gemma M. published the artcileModulation by Phosphonium Ions of the Activity of Mitotropic Agents Based on the Chemiluminescence of Luminols, HPLC of Formula: 638-45-9, the publication is Molecules (2022), 27(4), 1245, database is CAplus and MEDLINE.
Mitochondria-targeting drugs and diagnostics are used in the monitoring and treatment of mitochondrial pathologies. In this respect, a great number of functional compounds have been made mitotropic by covalently attaching the active moiety onto a triphenylphosphonium (TPP) cation. In this regard, luminol (probably the most widely known chemiluminescent mol.) has been employed for a number of biol. applications, including ROS detection. Hence, the photophys. interaction between the light-emitting species 3AP * and TPP cations needs to be evaluated, as it can add valuable information on the design of novel emission-based mitotropic systems. Author’s herein investigate the quenching effect of ethyltriphenylphosphonium cation onto substituted 3-aminophthalates. These were prepared in situ upon hydrolysis of the corresponding anhydrides, which were synthesized from 3-aminophthalimides. Steady-state fluorescence and time-resolved experiments were employed for the evaluation of a possible electron transfer quenching by phosphonium ions. A minor contribution of static quenching that was also detected is attributed to complex formation in the ground state. Accordingly, the chemiluminescence of luminol was indeed strongly reduced in the presence of phosphonium ions. Author’s results have to be taken into account during the design of new chemiluminescent mitotropic drugs or diagnostic agents of the luminol family.
Molecules published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, HPLC of Formula: 638-45-9.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com