Ohmomo, Yoshiro published the artcileSynthesis and evaluation of iodinated benzamide derivatives as selective and reversible monoamine oxidase B inhibitors, Related Products of iodides-buliding-blocks, the publication is Chemical & Pharmaceutical Bulletin (1992), 40(7), 1789-92, database is CAplus and MEDLINE.
A new series of iodinated analogs of N-(2-aminoethyl)benzamide were synthesized and evaluated for inhibitory potency and specificity toward monoamine oxidase type-B (MAO-B). Among them, N-(2-aminoethyl)-2-chloro-4-iodobenzamide hydrochloride (I) showed high inhibitory potency and selectivity against MAO-B. The type of MAO-B inhibition by I was noncompetitive and the inhibition constant (Ki) was 0.80 μM. Strong and selective in vivo MAO-B inhibition by I was also confirmed. The brain MAO-B inhibition by I was reversible and the enzyme activity completely returned to the control value 24h after administration. Compound I was, therefore, considered to be a candidate for advanced development as a radioiodinated ligand that may be useful for functional MAO-B studies in the living brain using single photon emission computer tomog.
Chemical & Pharmaceutical Bulletin published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Related Products of iodides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com