Kusche, Brian R. published the artcileNonactin biosynthesis: Setting limits on what can be achieved with precursor-directed biosynthesis, Product Details of C5H9IO2, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(4), 1233-1235, database is CAplus and MEDLINE.
Nonactin, produced by Streptomyces griseus ETH A7796, is a macrotetrolide assembled from nonactic acid. It is an effective inhibitor of drug efflux in multidrug resistant erythroleukemia K562 cells at sub-toxic concentrations and has been shown to possess both antibacterial and antitumor activity. As total synthesis is impractical for the generation of nonactin analogs the authors have studied precursor-directed biosynthesis as an alternative as it is known that nonactic acid can serve as a nonactin precursor in vivo. To determine the scope of the approach the authors prepared and evaluated a furan-based nonactic acid derivative, (I). Although no new nonactin analogs were detected when (I) was administered to S. griseus fermentative cultures, a significant inhibition of nonactin biosynthesis was noted (IC50 â?100 μM). Cell mass, nonactic acid production and the generation of other secondary metabolites in the culture were unaffected by (I) demonstrating that (I) selectively inhibited the assembly of nonactin from nonactic acid. While the authors were unable to generate new nonactin analogs the authors have discovered, however, a useful inhibitor that can be used to probe the mechanism of nonactin assembly with the ultimate goal of developing more successful precursor-directed biosynthesis transformations.
Bioorganic & Medicinal Chemistry Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Product Details of C5H9IO2.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com