Heald, Robert A. published the artcileAntitumor polycyclic acridines. 8.Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts, Product Details of C12H14IN, the publication is Journal of Medicinal Chemistry (2002), 45(3), 590-597, database is CAplus and MEDLINE.
Two short routes to novel methylated pentacyclic quinoacridinium salts have been devised. New compounds display telomerase-inhibitory potency (<1 μM) in the TRAP assay. 3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate ( RHPS4, NSC 714187) has a higher selectivity for triplex and quadruplex DNA structures than the 3,6,8,11,13-pentamethyl analog (RHPS3, NSC 714186) and a low overall growth-inhibitory activity in the NCI 60 cell panel (mean GI50 13.18 μM); in addition, the activity profile of NSC 714187 does not COMPARE with agents of the topoisomerase II class. Compound NSC 714187 is soluble in water, stable in the pH range of 5-9, efficiently transported into tumor cells, and is currently the lead structure for further elaboration in this new class of telomerase inhibitor.
Journal of Medicinal Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Product Details of C12H14IN.
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https://en.wikipedia.org/wiki/Iodide,
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