Feng, Huan published the artcileResponsive Fluorescence Probe for Selective and Sensitive Detection of Hypochlorous Acid in Live Cells and Animals, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Chemistry – An Asian Journal (2018), 13(18), 2611-2618, database is CAplus and MEDLINE.
The development of effective bioanal. methods for rapid, sensitive and specific detection of HOCl in vitro and in vivo plays a key role for better understanding the roles of this mol. in normal and diseased conditions, but remains challenging due to the highly reactive nature of HOCl and the complicated biol. conditions. A new fluorescence probe, PQI(I), was developed for monitoring of the HOCl level in biol. samples. PQI was easily synthesized by a one-step condensation reaction. Upon addition of HOCl, significant changes in the absorption spectra and the color of the solution were noticed, facilitating the “naked eye” detection of HOCl in PBS buffer. The fluorescence of PQI is significantly increased within a few seconds, leading to “OFF-ON” fluorescence response towards HOCl. The sensing mechanism, oxidation of thioether by HOCl, was confirmed by HRMS titration anal. PQI features a large Stokes shift, high sensitivity and selectivity, and rapid fluorescence response towards HOCl. Quant. detection of HOCl in single live cells was demonstrated through fluorescence imaging and flow cytometry anal. PQI was then successfully used in visualization of HOCl in live zebrafish and nude mice.
Chemistry – An Asian Journal published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com