Zorzi, Rodrigo Rocha published the artcileExploring 5-nitrofuran derivatives against nosocomial pathogens: synthesis, antimicrobial activity and chemometric analysis, Name: 4-Iodobenzohydrazide, the publication is Bioorganic & Medicinal Chemistry (2014), 22(10), 2844-2854, database is CAplus and MEDLINE.
The burden of nosocomial or health care-associated infection (HCAI) is increasing worldwide. According to the World Health Organization (WHO), it is severalfold higher in low- and middle-income countries. Considering multidrug-resistant infections, the development of new and more effective drugs is crucial. Here, two series (I and II) of 5-nitrofuran derivatives were designed, synthesized and assayed against microorganisms, including Gram-pos. and -neg. bacteria, and fungi. Sets I and II were composed by substituted-[N’-(5-nitrofuran-2-yl)methylene]benzhydrazide and 3-acetyl-5-(substituted-phenyl)-2-(5-nitro-furan-2-yl)-2,3-dihydro-1,3,4-oxadiazole compounds, resp. The selection of the substituent groups was based upon physicochem. properties, such as hydrophobicity and electronic effect. The compounds exhibited good activity against Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis. It is noteworthy that the compound 4-butyl-[N’-(5-nitrofuran-2-yl)methylene]benzhydrazide had a similar MIC value to vancomycin, which is the reference drug for multidrug-resistant S. aureus infections.
Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C10H14O, Name: 4-Iodobenzohydrazide.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com