Hong, Seunghee published the artcileDesign, Synthesis, and Evaluation of 3,5-Disubstituted 7-Azaindoles as Trk Inhibitors with Anticancer and Antiangiogenic Activities, Synthetic Route of 757978-19-1, the publication is Journal of Medicinal Chemistry (2012), 55(11), 5337-5349, database is CAplus and MEDLINE.
Tropomyosin-related kinase A (TrkA) is considered a promising target in the development of a therapeutic treatment of cancer and pain. Thus, a series of novel 7-azaindole-based Trk kinase inhibitors, e. g. I, were designed and synthesized through the structure-based design strategy. By varying the functional groups at the 3 and 5 positions of a 7-azaindole scaffold, the structure-activity relationships (SAR) profiles were explored and a series of potent Trk inhibitors were identified. Representative derivatives, including I, showed desirable activity in cellular proliferation and apoptosis assays. Moreover, these inhibitors exhibited noteworthy antiangiogenic activity.
Journal of Medicinal Chemistry published new progress about 757978-19-1. 757978-19-1 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Bromide,Iodide,Sulfamide,Benzene, name is 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, and the molecular formula is C13H8BrIN2O2S, Synthetic Route of 757978-19-1.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com