Fan, Yi Chiao published the artcilePhosphine/Palladium-Catalyzed Syntheses of Alkylidene Phthalans, 3-Deoxyisoochracinic Acid, Isoochracinic Acid, and Isoochracinol, SDS of cas: 500563-90-6, the publication is Organic Letters (2012), 14(13), 3264-3267, database is CAplus and MEDLINE.
In this study, we used sequential catalysis-PPh3-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans, e.g., I (R1 = H, R, R2 = H, OCH2Ph, OMe, CF3, etc., R3 = H, OCH2Ph, OMe, Me, R4 = H, Me, MeO), rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid II (X = none, Y = CO2H) isoochracinic acid II (X = O, Y = CO2H), and isoochracinol II (X = O, Y = CH2OH).
Organic Letters published new progress about 500563-90-6. 500563-90-6 belongs to iodides-buliding-blocks, auxiliary class Nitro Compound,Iodide,Benzene,Alcohol, name is (2-Iodo-4-nitrophenyl)methanol, and the molecular formula is C7H6INO3, SDS of cas: 500563-90-6.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com