An efficient and mild ortho-zincation of aromatics and heterocycles by using TMP2Mg·2LiCl in the presence of ZnCl2 was written by Dong, Zhi-Bing;Zhu, Wei-Hua;Zhang, Zhi-Guang;Li, Min-Zhi. And the article was included in Journal of Organometallic Chemistry in 2010.COA of Formula: C9H8ClIO2 The following contents are mentioned in the article:
A variety range of functionalized aryl and heteroaryl zinc reagents were efficiently generated by using TMP2Mg·2LiCl (TMP = 2,2,6,6-tetramethylpiperidinyl) in the presence of ZnCl2. The subsequently functionalization gave after reaction with electrophiles the expected polyfunctionalized products in good yields. E.g., metalation of pyrazine with ZnCl2, followed by TMP2Mg·2LiCl, then treatment with I2, gave 71% 2-iodopyrazine. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4COA of Formula: C9H8ClIO2).
Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.COA of Formula: C9H8ClIO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com