Asymmetric synthesis of chiral sulfoximines via the S-arylation of sulfinamides was written by Aota, Yusuke;Kano, Taichi;Maruoka, Keiji. And the article was included in Journal of the American Chemical Society in 2019.Category: iodides-buliding-blocks The following contents are mentioned in the article:
Optically active sulfoximines are a promising substructure in me-dicinal chem. However, a methodol. for preparing chiral sulfoximines in a stereoselective manner has been underdeveloped. Herein, an asym. synthesis of chiral sulfoximines having an aryl group by the newly developed sulfur-selective arylation of easily accessible chiral sulfinamides is reported. The utility of the pre-sent method is demonstrated by the asym. synthesis of a key intermediate of a COX-2 inhibitor. This study involved multiple reactions and reactants, such as Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3Category: iodides-buliding-blocks).
Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Category: iodides-buliding-blocks
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com