Catalyst free hydrazone ligation for protein labeling and modification using electron-deficient benzaldehyde reagents was written by Xu, Yang;Wang, Yu;Liu, Peiyuan;Chu, Guo-Chao;Xu, Huajian;Li, Yi-Ming;Wang, Jun;Shi, Jing. And the article was included in Organic & Biomolecular Chemistry in 2018.Product Details of 371764-70-4 The following contents are mentioned in the article:
Bioorthogonal reactions have emerged as valuable tools for site-specific protein labeling and modification in vitro and in vivo. Hydrazone and oxime ligation has recently attracted considerable attention for wide applications in the conjugation of biomols. However, this kind of reaction has suffered from slow kinetics under physiol. conditions and toxicity or complications of the reaction system due to catalysts. The authors have developed an electron-deficient benzaldehyde reagent, which can be easily equipped with various types of bio-functional mols. for catalyst-free hydrazone ligation. The reagent can be equipped with not only small mols. such as fluorescence dyes or drugs, but also macromols. like PEG. These can be precisely ligated to the C-terminus of proteins by an efficient hydrazone reaction at neutral pH and room temperature The new reagent based catalyst-free hydrazone ligation provides a practical approach for the site specific modification of proteins. This study involved multiple reactions and reactants, such as 2-Chloro-4-iodobenzonitrile (cas: 371764-70-4Product Details of 371764-70-4).
2-Chloro-4-iodobenzonitrile (cas: 371764-70-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Product Details of 371764-70-4
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com