Cu(I)-Catalyzed Asymmetric Arylation of Pyrroles with Diaryliodonium Salts toward the Synthesis of N-N Atropisomers was written by Xu, Qi;Zhang, Huan;Ge, Fang-Bei;Wang, Xiao-Mei;Zhang, Peng;Lu, Chuan-Jun;Liu, Ren-Rong. And the article was included in Organic Letters in 2022.Computed Properties of C17H18F3IO3S The following contents are mentioned in the article:
The copper(I) catalysis using a bis(phosphine) dioxide ligand could catalyze the desym. C-H arylation of prochiral bipyrroles was reported. More than 50 nitrogen-nitrogen atropisomers I [R1 = Ph, 3-ClC6H4, 2-naphthyl, etc.; R2 = Me, Et, Bn, etc.; R3 = Me, Et, i-Pr; R4 = H, Me; R1R4 = CH=CH-CH=CH; Ar = Ph, 4-MeC6H4, 3-ClC6H4, etc.] were achieved in good to excellent yields with excellent enantioselectivities (≤97% yield, ≤98% ee). The reaction proceeded under mild conditions with good functional group compatibility on arenes and diaryliodonium salts. Moreover, this principle enabled iterative arylation of the bipyrroles to enantioselectively arylate different positions during the catalysis of copper. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Computed Properties of C17H18F3IO3S).
Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Computed Properties of C17H18F3IO3S
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com