Vaidyanathan, Ganesan et al. published their research in Bioconjugate Chemistry in 2001 | CAS: 368435-46-5

(3-Amino-5-iodophenyl)methanol (cas: 368435-46-5) belongs to iodide derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Electric Literature of C7H8INO

Synthesis of ring- and side-chain-substituted m-iodobenzylguanidine analogues was written by Vaidyanathan, Ganesan;Shankar, Sriram;Zalutsky, Michael R.. And the article was included in Bioconjugate Chemistry in 2001.Electric Literature of C7H8INO The following contents are mentioned in the article:

With the goal of developing m-iodobenzylguanidine (MIBG) analogs with improved targeting properties especially for oncol. applications, several radioiodinated ring- and side-chain-substituted MIBG analogs were synthesized. Except for 3-[131I]iodo-4-nitrobenzylguanidine (I) and N-hydroxy-3-[131I]iodobenzylguanidine (II), the radioiodinated analogs were prepared at no-carrier-added levels from their resp. tin precursors. The radiochem. yields generally were in the range of 70-90% except for 3-amino-5-[131I]iodobenzylguanidine for which a radiochem. yield of about 40% was obtained. While the silicon precursor N1,N2-bis(tert-butyloxycarbonyl)-N1-(4-nitro-3-trimethylsilylbenzyl)guanidine did not yield 3-[131I]iodo-4-nitrobenzylguanidine, its deprotected derivative, N1-(4-nitro-3-trimethylsilylbenzyl)guanidine was radioiodinated in a modest yield of 20% providing 3-[131I]iodo-4-nitrobenzylguanidine. Exchange radioiodination of 3-iodo-4-nitrobenzylguanidine gave 3-[131I]iodo-4-nitrobenzylguanidine in 80% radiochem. yield. No-carrier-added [131I]NHIBG (III) was prepared from its silicon precursor N1-hydroxy-N3-(3-trimethylsilylbenzyl)guanidine in 85% radiochem. yield. The paired-label tissue uptake of 125I and 131I activity after injection of [125I]MIBG, I, II, and III is provided. This study involved multiple reactions and reactants, such as (3-Amino-5-iodophenyl)methanol (cas: 368435-46-5Electric Literature of C7H8INO).

(3-Amino-5-iodophenyl)methanol (cas: 368435-46-5) belongs to iodide derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Electric Literature of C7H8INO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com