Metal-Free Regioselective N2-Arylation of 1H-Tetrazoles with Diaryliodonium Salts was written by Saikia, Raktim Abha;Dutta, Anurag;Sarma, Bipul;Thakur, Ashim Jyoti. And the article was included in Journal of Organic Chemistry in 2022.Computed Properties of C19H22F3IO3S The following contents are mentioned in the article:
A simple, metal-free regioselective N2-arylation strategy for 5-substituted-1H-tetrazoles I (R1 = Ph, naphthalen-1-yl, benzyl, thiophen-2-yl, etc.) with diaryliodonium salts R2I+(R3)X– (R2 = Ph, 4-chlorophenyl, 2,4,6-trimethylphenyl, etc.; R3 = Ph, 4-chlorophenyl, 4-methoxyphenyl, 2,4,6-trimethylphenyl, etc.; X = OTF, OTs, BF4) to access 2-aryl-5-substituted-tetrazoles was described. Diaryliodonium salts with a wide range of both electron-rich and previously challenged electron-deficient aryl groups are applicable in this method. Diversely functionalized tetrazoles are tolerable also. A one-pot system to synthesize 2,5-diaryl-tetrazoles directly from nitriles was devised. The synthetic utility of this method is furthered extended to late-stage arylation of two biol. active mols. This study involved multiple reactions and reactants, such as Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3Computed Properties of C19H22F3IO3S).
Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Computed Properties of C19H22F3IO3S
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com