Silver-Promoted Coupling of Carbon Dioxide, o-Alkynylanilines and Diaryliodonium Salts: Straightforward Access to 4-Aryloxy-2-quinolinones was written by Qi, Chaorong;Guo, Tianzuo;Xiong, Wenfang;Wang, Lu;Jiang, Huanfeng. And the article was included in ChemistrySelect in 2017.HPLC of Formula: 139139-80-3 The following contents are mentioned in the article:
A silver-promoted three-component reaction of carbon dioxide, o-alkynylanilines I [R1 = 4-F, 4-CN, 4-ethylcyclohexyl, etc.; R2 = 4-F, 5-CH3, 2,4-(F)2, etc.] and diaryliodonium salts II (R3 = R4 = 4-F; R3 = 2-F, R4 = 4-OCH3; R3 = 3-CH3, R4 = 4-OCH3, etc.) using 1,4-diazabicyclo[2.2.2]octane (DABCO) as the base has been developed for the first time, which provides an efficient and straightforward protocol for the synthesis of a wide range of 4-aryloxy-substituted 2-quinolinones III (R1 = 4-Cl, 4-Br, 2-Cl, etc.; R2 = 7-CH3, 6-Cl, 6,8-(Cl)2, etc.; R3 = 2,4,6-trimethylphenyl, 3-CH3C6H4, 4-O2NC6H4, etc.) in moderate to excellent yields. Diverse functional groups such as halo, trifluoromethyl, cyano and nitro are well tolerated. Mechanistic studies indicated that 4-hydroxyl-2-quinolinone generated in-situ from o-alkynylanilines I and carbon dioxide might be the key intermediate for the reaction. This study involved multiple reactions and reactants, such as Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3HPLC of Formula: 139139-80-3).
Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 139139-80-3
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com