Bronsted acid-enhanced copper-catalyzed atroposelective cycloisomerization to axially chiral arylquinolizones via dearomatization of pyridine was written by Min, Xiao-Long;Zhang, Xiu-Lian;Yi, Wenbin;He, Ying. And the article was included in Nature Communications in 2022.Quality Control of 2-Bromo-1-iodonaphthalene The following contents are mentioned in the article:
Herein, the enantioselective synthesis of axially chiral arylquinolizones through an intramol. atroposelective cycloisomerization was reported. The reaction proceeds via the Bronsted acid-enhanced dearomatization of pyridine by a copper catalyst that allows for the formation of the desired products in excellent yields and enantioselectivities. The utility of this methodol. was illustrated by a synthesis on gram scale production and transformation of the products into chiral thiourea catalysts. Mechanistic studies demonstrate that Bronsted acid plays a significant role in promoting the reactivity of the reaction, while both the steric and electronic effects of aryl substituents in substrate play a role in controlling the stereoselectivity. This study involved multiple reactions and reactants, such as 2-Bromo-1-iodonaphthalene (cas: 676267-05-3Quality Control of 2-Bromo-1-iodonaphthalene).
2-Bromo-1-iodonaphthalene (cas: 676267-05-3) belongs to iodide derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Quality Control of 2-Bromo-1-iodonaphthalene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com